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FLASH GENE
Symbol TRIM43 contributors: mct - updated : 23-09-2014
HGNC name tripartite motif-containing 43
HGNC id 19015
Location 2q11.1      Physical location : 96.257.765 - 96.265.467
Synonym symbol(s) TRIM43A
DNA
TYPE functioning gene
STRUCTURE 7.75 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D2S2154 - D2S2159 - TRIM43 - D2S113 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1642 52.1 446 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger
  • a B-box domain
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a B30.2/SPRY domain
  • HOMOLOGY
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • identifying specific cell compartments
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    TRIM43 and MBD3L2 are already overexpressed in FSHMD1A fetal quadriceps biopsies, at similar levels to those observed in adult FSHMD1A quadriceps biopsies
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • TRIM43 genes will be useful stage-specific markers for the study of preimplantation embryos
  • Therapy target
    ANIMAL & CELL MODELS