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FLASH GENE
Symbol TRIM38 contributors: mct - updated : 24-10-2014
HGNC name tripartite motif-containing 38
HGNC id 10059
Location 6p22.2      Physical location : 25.963.070 - 25.985.350
Synonym name
  • Ro/SSA ribonucleoprotein homolog;
  • ring finger protein 15
  • zinc finger protein RoRet
  • ring finger protein 15
  • Synonym symbol(s) RORET, RNF15, MGC8946
    DNA
    TYPE functioning gene
    STRUCTURE 24.64 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 5629 - 465 - 2008 1883647
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunelymph node   highly
     spleen   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING finger domain
  • a B box type zinc finger domain
  • a coiled-coil domain
  • HOMOLOGY
    intraspecies homolog to Ro/SSA protein
    homolog to BTN
    Homologene
    FAMILY
  • B box family, RBCC (TRIM family)
  • C-IV TRIM family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having as others TRIM proteins a common function: by means of homo-multimerization they identify specific cell compartments
  • function for TRIM38 to prevent excessive TLR-induced inflammatory responses through proteasomal degradation of TRAF6
  • is a negative regulator for TLR and DDX58-mediated IFNB production by targeting TAB3 for ubiquitination and subsequent proteasome-mediated degradation
  • may act as a novel negative regulator for TLR3-mediated type I interferon signaling by targeting TICAM1 for degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • bound to TRAF6 and promoted K48-linked polyubiquitination, which led to the proteasomal degradation of TRAF6
  • interacted with TAB3, which is required for TLR-induced IFNAR3 activation and IFNB production
  • negatively regulates TLR3-mediated type I interferon signaling by targeting TIR domain-containing adaptor inducing IFNB (TICAM1)
  • TRIM38 negatively regulates TLR3/4-mediated innate immune and inflammatory responses by two sequential and distinct mechanisms
  • cell & other
    REGULATION
    induced by IFN-gamma and LPS
    TLR stimulation in an NFKB-dependent manner in macrophages
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS