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FLASH GENE
Symbol TRIM37 contributors: mct - updated : 13-04-2007
HGNC name tripartite motif-containing 37
HGNC id 7523
Corresponding disease
MUL Mulibrey nanism
Location 17q23.2      Physical location : 57.060.001 - 57.184.266
Synonym name
  • RING-B-box-coiled-coil protein
  • Mulibrey nanism
    • Synonym symbol(s) KIAA0898, MUL, POB1, TEF3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 124.00 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - MTMR3 - SEPT4 - RAD51C - TRIM37 - qter
    Authors Avela (00)
    regionally located in the 17q23 amplicon, in breast cancer
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4488 - 964 expressed in testis, but is prominent in other tissues Hamalainen (2006)
    - - 3588 - 964 expressed in testis Hamalainen (2006)
  • an alternative termination codon and 3'untranslated region (UTR) transcribed from an exon 16 kb downstream from exon 24
    		•
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING finger
  • a B box type 2 motif
  • a coiled-coil domain
  • a MATH (meprin and tumour-necrosis factor receptor-associated factor homology) domain
  • a nuclear coil localization signal (NLS)
  • two aspartate-glutamate serine (DES) rich sequence at the C terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • tripartite motif (TRIM, RING-B-box-coiled-coil)-family
  • C-VIII TRIM family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • putatively involved in development and oncogenesis
  • acting as a TRIM domain-dependent E3 ubiquitin ligase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by several mechanisms: through nonsense surveillance of non-functional transcripts, as well as through 3 prime UTR regulatory sequences and/or naturally occurring antisense RNAs especially in testis
    ASSOCIATED DISORDERS
    corresponding disease(s) MUL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS