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FLASH GENE
Symbol TRIM34 contributors: npt - updated : 31/10/2008
HGNC name tripartite motif-containing 34
HGNC id 10063
Location 11p15.4      Physical location : 5.641.173 - 5.665.623
Synonym name
  • interferon responsive finger protein 1
  • RING finger protein 21
  • Synonym symbol(s) IFP1, RNF21
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 24.45 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 2326 - 488 - Orimo
  • having an alternate 5' UTR, as compared to variant 1
  • encoding the same protein than variant 1
  • also known as middle form
  • 4 splicing 959 - 270 placenta, spleen, colon, blood leukocytes Orimo
  • lacking several 3' exons but including a unique segment in its 3' end as compared to variant 1
  • also known as short form
  • 8 splicing 2302 - 488 - -
  • also called alpha
  • also known as middle form
  • encoding the same protein than variant 4
  • 9 splicing 2222 - 243 - -
  • also called epsilon
  • lacking an internal segment compared to variant 1
  • initiating translation from a downstream start codon compared to variant 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     salivary gland   predominantly
    Lymphoid/Immunespleen    
    Reproductivefemale systemplacenta  moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING-type zinc finger
  • two B box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C terminal B30.2/SPRY domain
  • RFP-like domain
  • HOMOLOGY
    intraspecies paralog to TRIM6, TRIM5
    Homologene
    FAMILY
  • TRIM/RBCC family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a potential mediator of interferon biological action
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    induced by IFNA (middle form)
    IFN-gamma and LPS
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS