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FLASH GENE
Symbol TRIM31 contributors: mct/npt - updated : 02-04-2020
HGNC name tripartite motif-containing 31
HGNC id 16289
Location 6p22.1      Physical location : 1.318.453 - 30.080.867
Synonym name
  • HCGI protein
  • ring finger protein
    • Synonym symbol(s) RNF, HCGI, HCG1, C6orf13
    EC.number 2.3.2.27
    DNA
    TYPE like-sequence
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 10.19 kb     9 Exon(s)    single Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D6S306 - TRIM31 - D6S273 - D6S1615 - cen
    Authors UCSC (2009)
    regionally located located 170 kb centromeric to HLA-A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2027 48.1 425 - 2018 29864908
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly Homo sapiens
     intestinesmall intestineileum highly Homo sapiens
     liver   moderately
    Reproductivemale systemtestis  highly
    Respiratorylung   moderately
     respiratory tracttrachea  moderately
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING zinc finger
  • a B box domain type 2
  • a CXXC motif
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • C-terminal PRY and SPRY (Spla kinase and ryanodine receptor) domains (Watanabe 2009)
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Trim31 (52.8 pc)
    homolog to murine Trim31 (54.6 pc)
    Homologene
    FAMILY
  • B box family, RBCC (TRIM family)
  • tripartite motif-containing protein (TRIM) family
  • E3 ubiquitin ligase family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text
  • associated with the mitochondria and lysosomes as punctate structures
    • basic FUNCTION
  • attenuates SRC1 signaling via p52SHC under anchorage-independent growth conditions and is potentially associated with growth activity of cells in the gastrointestinal tract (Watanabe 2009)
  • had the ability to regulate cell proliferation negatively in gastric adenocarcinoma
  • shows the most rapid kinetics of induction during retinoid-induced growth arrest of breast carcinoma cell (Watanabe 2009)
  • may play an important role in gastrointestinal tissue-specific regulation of cell proliferation (Watanabe 2009)
  • might serve as a tumor suppressor in non-small cell lung cancer
  • TRIM31 expression is tightly controlled in a tissue-specific manner, and expression of TRIM31 may associate with the epithelial function of the intestine mucosa or intestinal immune homoeostasis
  • TRIM31 is involved in the autophagy process
  • TRIM31-induced autophagy is likely essential for restricting the growth of Shigella in epithelial cells
  • TRIM31 limits NLRP3 inflammasome activity under physiological conditions
  • is a potential therapeutic target for the intervention of NLRP3 inflammasome related diseases
  • forms prion-like aggregates to activate an innate antiviral immune response after viral infection 2)
  • mediated chronic inflammation via the NFKB1 pathway to promote invasion and metastasis in colorectal cancer (CRC)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacts with SHC1
  • MAGEA1 interaction stimulates TRIM31 ubiquitin-ligase activity
  • considerable interaction between TRIM31 and CALCOCO2
  • TRIM31 is a feedback suppressor of NLRP3 inflammasome
  • TRIM31, an E3 ubiquitin ligase of the TRIM family of proteins, is a regulator of MAVS aggregation
  • TRIM31 exerted its oncogenic effect by directly interacting with the tuberous sclerosis complex (TSC) 1 and TSC2 complex, the upstream suppressor of MTOR pathway
    • cell & other
    REGULATION
    induced by IFN-gamma and LPS
    Other cellular level of TRIM31, is regulated by multiple mechanisms including the ubiquitin-proteasome system
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric adenocarcinoma
    tumoral       gain of function
    in Bladder cancer patients when compared with normal subjects
    tumoral     --over  
    in high-grade glioma tissues
    tumoral     --over  
    significantly upregulated in liver cancer tissues compared with paired distal non-cancerous liver tissues from HCC patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a valuable detective marker in primary colorectal cancer (CRC)
  • independent prognostic factor for glioma patients
    • Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    TRIM31 may be an effective target for glioma intervention
    cancerdigestiveliver
    potential therapeutic strategy against HCC by targeting TRIM31
    ANIMAL & CELL MODELS
  • Trim31-deficient mice were more susceptible to infection with RNA virus than were wild-type mice