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FLASH GENE
Symbol TRIM3 contributors: mct - updated : 11-09-2010
HGNC name tripartite motif-containing 3
HGNC id 10064
Location 11p15.4      Physical location : 6.469.843 - 6.495.205
Synonym name
  • brain-expressed ring finger protein
  • ring finger protein 22
  • tripartite motif protein TRIM3
  • Synonym symbol(s) HAC1, BERP, RNF22, RNF97, FLJ16135
    DNA
    TYPE functioning gene
    STRUCTURE 25.36 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390084 11 similar to Olfactory receptor 56A4 LOC338751 11p15.4 similar to Olfactory receptor 52L1 LOC390085 11 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC120793 11p15.4 similar to Olfactory receptor 56A4 LOC120796 11p15.4 similar to Olfactory receptor 56A1 LOC390086 11 similar to Olfactory receptor 56A1 LOC390087 11 similar to Olfactory receptor 52L2 OR52X1P 11p15.3 olfactory receptor, family 52, subfamily X, member 1 pseudogene LOC196335 11p15.4 similar to Olfactory receptor 56B4 LOC390088 11 similar to seven transmembrane helix receptor LOC390089 11 hypothetical gene supported by AF359415 LOC255725 11p15.4 similar to seven transmembrane helix receptor LOC120787 11p15.4 similar to seven transmembrane helix receptor MGC34805 11p15.4 hypothetical protein MGC34805 DKFZP566M1046 11p15.4 hypothetical protein DKFZp566M1046 CNGA4 11p15.4 cyclic nucleotide gated channel alpha 4 CCKBR 11p15.4 cholecystokinin B receptor PRKCDBP 11p15.5-p15.4 protein kinase C, delta binding protein SMPD1 11p15.3 sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) APBB1 11p15.5 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) HPX 11p15.5 hemopexin TRIM3 11p15.5 tripartite motif-containing 3 ARFIP2 11p15 ADP-ribosylation factor interacting protein 2 (arfaptin 2) FXC1 11p15.2-p15.5 fracture callus 1 homolog (rat) LOC390090 11 similar to voltage-dependent anion channel 1 FLJ35709 11p15.4 hypothetical protein FLJ35709 LOC387749 11 hypothetical gene supported by BX647806 LOC196337 11p15.4 hypothetical protein LOC196337 LOC387750 11 similar to SI:zC220F6.1 (novel protein similar to human dynein heavy chain (DHC)) FLJ32752 11p15.4 hypothetical protein FLJ32752 KIAA0409 11p15.5-p15.2 hypothetical protein FLJ32752 ILK 11p15.3 integrin-linked kinase TAF10 11p15.3 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa CLN2 11p15.3 ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease) PCDH16 11p15.4 protocadherin 16 dachsous-like (Drosophila) MRPL17 11p15.5-p15.4 mitochondrial ribosomal protein L17 LOC387751 11 similar to very large inducible GTPase-1 LOC338755 11p15.4 similar to Olfactory receptor 2AG1 (HT3) LOC144125 11p15.4 similar to Olfactory receptor 2AG1 (HT3) OR6A1 11p15.5 olfactory receptor, family 6, subfamily A, member 1 JCG6 11p15.4 olfactory receptor-like protein JCG6 LOC341276 11p15.4 similar to hP4 olfactory receptor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 3059 80.7 744 - El Husseini (2001)
    also called variant 1/isoform alpha
    12 splicing 2894 80.7 744 - El Husseini (2001)
    also called variant 2/isoform beta
    - splicing 2023 72 665 - El Husseini (2001)
    also called variant 3/isoform gamma
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Nervousbrainhindbraincerebellum predominantly
    Reproductivefemale systemuteruscervix moderately
     female systembreastmammary gland highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal RING zinc finger
  • a B box domain type 1 and type 2
  • linked to a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • two zinc binding domains
  • a C terminal B30-2
  • RFP-like domain
  • six NHL repeats
  • a filamin repeat
  • conjugated
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Trim3
    ortholog to murine Trim3
    Homologene
    FAMILY
  • TRIM/RBCC family
  • CATEGORY motor/contractile , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text growth cone
    basic FUNCTION
  • organelle transport and neurite outgrowth
  • putatively anchoring MYO5A in particular cell domains via its interaction with alpha actinin 4, ACTN4
  • E3 ligase that mediates activity-dependent turnover of PSD scaffold proteins and is a negative regulator of dendritic spine morphology (Hung 2010)
  • may act at a posttranscriptional level to regulate the intracellular trafficking of GABAA receptor (Cheung 2010)
  • unique TP53-regulated gene that modulates seizure susceptibility and GABAAR cell surface expression (Cheung 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , locomotion , cellular trafficking transport , neurogenesis
    text transport of organelles
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tail domain of myosin Va
  • alpha actinin 4 (ACTN4)
  • specific E3 ubiquitin ligase for the PSD scaffold GKAP1/DLGAP1 (Hung 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    frequently deleted in several types of cancers
    tumoral   LOH    
    in malignant gliomas (Boulay 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • BERP-deficient miceexhibit increased resistance to pentylenetetrazol-induced seizures (Cheung 2010)