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FLASH GENE
Symbol TRIM29 contributors: mct - updated : 18-01-2023
HGNC name tripartite motif-containing 29
HGNC id 17274
Location 11q23.3      Physical location : 119.981.994 - 120.008.863
Synonym name
  • ataxia-telangiectasia group D-associated protein
    • Synonym symbol(s) ATDC, FLJ36085
    DNA
    TYPE functioning gene
    STRUCTURE 26.83 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure
  • KLF4 can bind specific site in the promoter of TRIM29 to transactivate its transcription
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text multiple spliced variants
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3018 65.77 588 - 2001 11331580
    9 splicing 2297 - 327 - 2001 11331580
    - splicing 2400 63.3 570 - 2000 10719033
    eliminating most of exon 1
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Reproductivefemale systemuteruscervix highly
     male systemprostate   
    Respiratoryrespiratory tractlarynx  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal B box domain type 1 and type 2
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • two zinc binding domains
  • four zinc finger motifs in a B-box domain
  • having not a RING finger
  • RFP-like domain
  • a C terminal B30-2
    • HOMOLOGY
    Homologene
    FAMILY
  • B box family, RBCC (TRIM family)
  • RING-less group of TRIM protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    basic FUNCTION
  • mediating estrogen action in various target organs
  • having radiosensitivity suppressor functions
  • increases cell proliferation via inhibition of TP53 nuclear activities
  • functions as an oncogene that promotes tumor growth
  • TRIM29 functions likely as a scaffold protein to assemble DNA repair proteins into chromatin followed by efficient activation of DNA damage response (DDR)
  • regulates negatively the host innate immune response to RNA virus, which could be employed by RNA viruses for viral pathogenesis
  • promotes DNA virus infections by inhibiting innate immune response
  • is a negative regulator of NK cell functions and may have important clinical implications
  • involved in the formation of homodimers and heterodimers in relation to DNA binding, having a role in carcinogenesis, DNA damage signaling, and the suppression of radiosensitivity
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS immunity/defense
    text suppression of radiosensitivity
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • protein kinase C, intermediate filament, vimentin which is a protein kinase C substrate
  • binds TP53, and this interaction is potentially fine-tuned by posttranslational acetylation of lysine 116 on TRIM29
  • binds to KAT5, which has been reported as a cellular acetyltransferase protein
  • interacting with HDAC9 (deacetylates TRIM29, alters the ability of TRIM29 to associate with TP53, and consequently inhibits the cell proliferation-promoting activity of TRIM29)
  • TRIM29 regulates the TP63-mediated pathway and the behavior of cervical cancer cells
  • TRIM29 is required for efficient recruitment of TP53BP1 to facilitate the nonhomologous end-joining (NHEJ) pathway and thereby suppress the HR pathway in response to DNA DSBs.
  • KLF4 is an important transcription factor on regulating TRIM29 expression and modulates the keratin network
  • SETBP1 is a crucial target of TRIM29, and TRIM29 facilitated SETBP1 transcriptional activation via the VEZF1 transcription factor
  • TRIM29 interacts with keratins and FAM83H to regulate keratin distribution
    • cell & other
    REGULATION
    Other regulated by HDAC9 (deacetylation of Lys116 of TRIM29 by HDAC9 is a critical step in the regulation of TRIM29 functions by HDAC9)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in many human cancers (
    tumoral     --over  
    in most invasive pancreatic cancers and pancreatic cancer precursor lesions
    tumoral     --low  
    in prostate and breast cancer
    tumoral     --over  
    high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression in gastrointestinal tumor
    tumoral        
    in Cutaneous Squamous Cell Carcinoma
    tumoral     --over  
    in gastric cancer tissues compared with their corresponding normal tissues
    tumoral       gain of function
    in cervical cancer tissues when compared with the matched adjacent cervical tissues
    tumoral       loss of function
    could inhibit the growth and proliferation partly through regulation of CCNE in esophageal squamous cell carcinoma (ESCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker may be a potential prognostic biomarker for cervical cancer
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveuterus
    therapeutic target for cervical cancer
    ANIMAL & CELL MODELS
  • TRIM29 -/- mice have lower adenovirus titers in the lung, and are resistant to lethal herpes simplex virus-1 infection due to enhanced production of type I interferon