Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TRIM25 contributors: mct - updated : 14-03-2015
HGNC name tripartite motif-containing 25
HGNC id 12932
Location 17q22      Physical location : 54.965.270 - 54.991.409
Synonym name
  • estrogen-responsive finger protein
  • zinc finger protein 147 (estrogen-responsive finger protein)
  • RING finger protein 147
  • Synonym symbol(s) EFP, Z147, ZNF147, RNF147
    EC.number 6.3.2.19
    DNA
    TYPE functioning gene
    STRUCTURE 26.14 kb     9 Exon(s)
    regulatory sequence Binding site
    text structure
  • no TATA
  • E box and other regulatory elements in the 5'UTR
  • MAPPING cloned Y linked N status confirmed
    Map cen - D17S1799 - D17S1607 - TRIM25 - D17S957 - D17S1605 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 5744 70.8 630 - 2008 18948594
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland highly
    cell lineage
    cell lines MCF breast cancer cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING zinc finger (C3HC4)
  • a B-box domain
  • a coiled-coil domain
  • a C-terminal B30.2/SPRY domain, interacting with the N-terminal CARDs of DDX58 (this interaction effectively delivers the Lys 63-linked ubiquitin moiety to the N-terminal CARDs of DDX58)
  • conjugated PhosphoP , MetalloP
    HOMOLOGY
    interspecies homolog to rattus Trim25 (74.2 pc)
    homolog to murine Trim25 (74.4 pc)
    Homologene
    FAMILY
  • zinc finger protein family
  • tripartite motif (TRIM) family
  • C-IV TRIM family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • predominantly cytoplasmic
  • focal adhesion
  • basic FUNCTION
  • mediating estrogen action in various target organs
  • may act as a transcription factor, similar to several other members of the TRIM family
  • controlling breast cancer growth through ubiquitin-dependent proteolysis of 14-3-3-sigma
  • essential not only for DDX58 ubiquitination but also for DDX58-mediated interferon- production and antiviral activity in response to RNA virus infection
  • key player in oestrogen-mediated degradation of KLF5
  • is an E3 ubiquitin ligase mediating oestrogen-induced ZFHX3 protein degradation
  • E3 ubiquitin ligases, TRIM25 and TRIM71 are validated as RNA-binding proteins (RBPs), revealing a potential link between RNA biology and protein-modification pathways
  • TRIM25 is a bona fide ZC3HAV1 cofactor that leads to increased ZC3HAV1 modification enhancing its translational inhibition activity
  • modulates the target RNA binding activity of ZC3HAV1
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacts with 14-3-3sigma, which is known as a cell cycle brake that causes G2 arrest and expressed in normal mammary glands
  • binds the DDX58 first CARD and subsequently ubiquitinates its second CARD
  • RNF135 was dispensable for DDX58 RNA binding activity but required for TRIM25 to activate DDX58
  • polyubiquitylation of GPI requires cooperative interaction between AMFR and the ubiquitin ligase TRIM25
  • TRIM25, a ubiquitin E3 ligase, is required for the antiviral activity of ZC3HAV1
  • cell & other
    REGULATION
    induced by estrogen
    repressed by RBCK1/RNF31/ LUBAC specifically suppresses DDX58 ubiquitination and activation by inducing TRIM25 degradation and inhibiting TRIM25 interaction with DDX58
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS