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FLASH GENE
Symbol TRIM22 contributors: mct/npt - updated : 31-03-2012
HGNC name tripartite motif-containing 22
HGNC id 16379
Location 11p15.4      Physical location : 5.710.918 - 5.732.092
Synonym name
  • stimulated trans-acting factor
  • 50 kDa-stimulated trans-acting factor
  • RING finger protein 94
    • Synonym symbol(s) STA50, GPSTAF50, RNF94
    DNA
    TYPE functioning gene
    STRUCTURE 21.28 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   HRE
    text structure
  • inducible interferon
  • a special cis-element named 5prime extended IFN-stimulating response element (5&
    • 8242;eISRE) in the TRIM22 promoter region that was crucial for IFNg-induced TRIM22 expression
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3099 - 494 - 2011 21683060
    8 - 3111 56.8 498 - 2011 21683060
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivefemale systemovary   
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal RING zinc finger
  • two B box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C terminal B30-2, RFP-like domain
  • B30.2/SplA and ryanodine receptor (SPRY) domain, and AAs 491-494 specifically are essential for nuclear localization and NB (nuclear bodies) formation
    • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • B box family
  • TRIM/RBCC family
  • C-IV TRIM family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • localized to both nucleus and cytosol in primary human mononuclear cells, as well as in the human osteosarcoma cell line
  • colocalizes with the centrosome independently of cell cycle phase
    • basic FUNCTION
  • involved in the transduction of IFN antiviral action
  • could exert antiproliferative effects
  • probably has an activation stage-specific role connected to the paracrine crosstalk during T lymphocyte activation
  • could be involved in proliferation and/or differentiation of leukemic cells
  • might function as a nuclear E3 ubiquitin ligase in the nucleus and influences the stability of its substrates through ubiquitylation in the nucleus, thus regulating subsequent biological events
  • involved in antiviral immunity against hepatitis B virus (HBV)
  • exhibits anti-HBV activity by acting as a transcriptional suppressor, and may play an important role in the clearance of HBV
  • important functions of TRIM22 such as regulation of viral replication and protein degradation may take place in the centrosome
  • likely acts as an antiviral effector
  • involved in the activation of NFKB, and is potentially a positive regulator of NFKB-mediated transcription
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TP53 target gene, playing an important role in cell proliferation
  • SMARCA4 plays a crucial role in IFNG-induced TRIM22 expression
    • cell & other
    REGULATION
    induced by IFN-gamma and LPS
    inhibited by strongly downregulated during T cell activation by anti CD28 and anti CD2 monoclonal antibodies
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS