Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TRIM22 contributors: mct/npt - updated : 31-03-2012
HGNC name tripartite motif-containing 22
HGNC id 16379
Location 11p15.4      Physical location : 5.710.918 - 5.732.092
Synonym name
  • stimulated trans-acting factor
  • 50 kDa-stimulated trans-acting factor
  • RING finger protein 94
  • Synonym symbol(s) STA50, GPSTAF50, RNF94
    DNA
    TYPE functioning gene
    STRUCTURE 21.28 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   HRE
    text structure
  • inducible interferon
  • a special cis-element named 5prime extended IFN-stimulating response element (5&
  • 8242;eISRE) in the TRIM22 promoter region that was crucial for IFNg-induced TRIM22 expression
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390056 11 similar to Olfactory receptor 51B4 (HOR5beta1) OR51B2 11p15 olfactory receptor, family 51, subfamily B, member 2 LOC390057 11 similar to MOR 5beta2 LOC390058 11 similar to HOR5Beta6 LOC390059 11 similar to HOR5Beta7 OR51J1P 11p15.3 olfactory receptor, family 51, subfamily J, member 1 pseudogene LOC390061 11 similar to Olfactory receptor 51Q1 LOC390062 11 similar to olfactory receptor MOR12-1 LOC390063 11 similar to Olfactory receptor 51I1 (HOR5beta11) LOC390064 11 similar to Olfactory receptor 51I2 (HOR5beta12) LOC390065 11 similar to HOR5Beta13 LOC390066 11 similar to Olfactory receptor 52D1 (HOR5beta14) UBQLN3 11p15 ubiquilin 3 MGC20470 11p15.4 hypothetical protein MGC20470 LOC338642 11p15.4 similar to RIKEN cDNA E030002O03 LOC390067 11 similar to seven transmembrane helix receptor LOC390068 11 similar to olfactory receptor MOR31-7 LOC143631 11p15.4 similar to olfactory receptor MOR31-6 LOC390069 11 similar to olfactory receptor MOR31-12 LOC340980 11p15.4 similar to seven transmembrane helix receptor TRIM6 11p15.4 tripartite motif-containing 6 TRIM34 11p15 tripartite motif-containing 34 TRIM5 11p15 tripartite motif-containing 5 TRIM22 11p15 tripartite motif-containing 22 LOC390070 11 similar to olfactory receptor MOR38-2 LOC390071 11 similar to seven transmembrane helix receptor LOC387748 11 similar to seven transmembrane helix receptor LOC390072 11 similar to Olfactory receptor 52N4 LOC390073 11 similar to Olfactory receptor 56B2 LOC390074 11 similar to Olfactory receptor 52N5 LOC390075 11 similar to Olfactory receptor 52N1 LOC390076 11 similar to olfactory receptor MOR34-7 LOC390077 11 similar to Olfactory receptor 52N2 LOC390078 11 similar to Olfactory receptor 52E6 LOC390079 11 similar to Olfactory receptor 52E6 LOC390080 11 similar to olfactory receptor MOR32-1 LOC390081 11 similar to Olfactory receptor 52E4 LOC390082 11 similar to Olfactory receptor 52E5
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3099 - 494 - 2011 21683060
    8 - 3111 56.8 498 - 2011 21683060
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivefemale systemovary   
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal RING zinc finger
  • two B box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C terminal B30-2, RFP-like domain
  • B30.2/SplA and ryanodine receptor (SPRY) domain, and AAs 491-494 specifically are essential for nuclear localization and NB (nuclear bodies) formation
  • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • B box family
  • TRIM/RBCC family
  • C-IV TRIM family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • localized to both nucleus and cytosol in primary human mononuclear cells, as well as in the human osteosarcoma cell line
  • colocalizes with the centrosome independently of cell cycle phase
  • basic FUNCTION
  • involved in the transduction of IFN antiviral action
  • could exert antiproliferative effects
  • probably has an activation stage-specific role connected to the paracrine crosstalk during T lymphocyte activation
  • could be involved in proliferation and/or differentiation of leukemic cells
  • might function as a nuclear E3 ubiquitin ligase in the nucleus and influences the stability of its substrates through ubiquitylation in the nucleus, thus regulating subsequent biological events
  • involved in antiviral immunity against hepatitis B virus (HBV)
  • exhibits anti-HBV activity by acting as a transcriptional suppressor, and may play an important role in the clearance of HBV
  • important functions of TRIM22 such as regulation of viral replication and protein degradation may take place in the centrosome
  • likely acts as an antiviral effector
  • involved in the activation of NFKB, and is potentially a positive regulator of NFKB-mediated transcription
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TP53 target gene, playing an important role in cell proliferation
  • SMARCA4 plays a crucial role in IFNG-induced TRIM22 expression
  • cell & other
    REGULATION
    induced by IFN-gamma and LPS
    inhibited by strongly downregulated during T cell activation by anti CD28 and anti CD2 monoclonal antibodies
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS