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FLASH GENE
Symbol TRIM17 contributors: SGE/pgu - updated : 02/07/2008
HGNC name tripartite motif-containing 17
HGNC id 13430
Location 1q42      Physical location : 228.595.637 - 228.604.583
Synonym name
  • ring finger protein 16
  • testis RING finger protein
  • RING-B-box-coiled-coil protein
  • RING finger protein terf
  • Synonym symbol(s) TERF, RBCC, RNF16
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MGC15634 1q42.13 hypothetical protein MGC15634 FLJ12517 1q42.13 hypothetical protein FLJ12517 IMAGE3451454 1q42.13 SVAP1 protein MPN2 1q42.13 marapsin 2 WNT9A 1q42 wingless-type MMTV integration site family, member 9A LOC340346 1q42.13 hypothetical gene supported by AK093729; AK096776; AL117642 LOC391173 1 similar to capicua homolog WNT3A 1q42 wingless-type MMTV integration site family, member 3A DKFZp434C0923 1q42.13 hypothetical protein DKFZp434C0923 ARF1 1q42 ADP-ribosylation factor 1 C1orf35 1q42.13 chromosome 1 open reading frame 35 MRPL55 1p36.3 mitochondrial ribosomal protein L55 LOC391174 1 similar to hypothetical protein FLJ22875 GUK1 1q32-q41 guanylate kinase 1 GJA12 1q41-q42 gap junction protein, alpha 12, 47kDa LOC200205 1q42.13 hypothetical protein LOC200205 FLJ14124 1q42.13 hypothetical protein FLJ14124 KIAA1639 1q42.13 KIAA1639 protein TRIM11 1q42.13 tripartite motif-containing 11 TRIM17 1q42 tripartite motif-containing 17 HIST3H3 1q42 histone 3, H3 LOC391175 1 similar to 60S ribosomal protein L23a HIST3H2A 1q42.13 histone 3, H2a HIST3H2BB 1q42.13 histone 3, H2bb HIST3H2BA 1 histone 3, H2ba LOC149603 1q42.13 hypothetical protein LOC149603 FLJ31401 1q42.13 hypothetical protein FLJ31401 LOC388750 1 similar to Ferritin heavy chain (Ferritin H subunit) ARHU 1q42.11-q42.3 ras homolog gene family, member U LOC388751 1 LOC388751
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1851 54 477 - 2001 11331580
  • encoding the same isoform than variant 2
  • 7 splicing 1815 54 477 - 2001 11331580
  • lacking a segment in the 5' UTR compared to variant 1
  • encoding the same isoform than variant 1
  • 7 splicing 1737 51 450 - 2001 11331580
  • lacking a segment in the 5' region compared to variant 1, resulting in translation initiation from a downstream AUG codon
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunespleen   predominantly
    Nervousbrain   moderately
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tractlarynx  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING zinc finger
  • two B box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM), required for the interaction with ZWINT
  • a C terminal B30.2/SPRY, RFP-like domain
  • HOMOLOGY
    interspecies homolog to rattus Trim17 (74.8 pc)
    homolog to murine Trim17 (76.5 pc)
    Homologene
    FAMILY
  • B box family
  • RBCC (TRIM family)
  • TRIM/RBCC protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potential transcriptional regulation of spermatogenesis
  • may have an E3-ubiquitin ligase activity
  • one of the critical E3 ubiquitin ligases involved in the control of neuronal apoptosis upstream of mitochondria
  • its E3 activity is both necessary and sufficient for the initiation of neuronal apoptosis
  • causes protein degradation of ZWINT and negatively regulates cell proliferation
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ions Zn2+
  • protein
  • interacting with TRIM44
  • interacted with ZWINT and overexpression of TRIM17 caused down-regulation of protein levels of ZWINT in mammalian cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS