Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TRIM17 contributors: SGE/pgu - updated : 03-06-2020
HGNC name tripartite motif-containing 17
HGNC id 13430
Location 1q42.13      Physical location : 228.595.637 - 228.604.583
Synonym name
  • ring finger protein 16
  • testis RING finger protein
  • RING-B-box-coiled-coil protein
  • RING finger protein terf
    • Synonym symbol(s) TERF, RBCC, RNF16
    EC.number 2.3.2.27
    DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 2064 54 477 - 2019 30042493
  • encoding the same isoform than variant 2
    • 7 splicing 2028 54 477 - 2019 30042493
  • lacking a segment in the 5' UTR compared to variant 1
  • encoding the same isoform than variant 1
    • 7 splicing 1737 51 450 - 2019 30042493
  • lacking a segment in the 5' region compared to variant 1, resulting in translation initiation from a downstream AUG codon
    • 6 - 1761 - 343 - 2019 30042493
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunespleen   predominantly
    Nervousbrain   moderately
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tractlarynx  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING zinc finger
  • two B box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM), required for the interaction with ZWINT
  • a C terminal B30.2/SPRY, RFP-like domain
    • HOMOLOGY
    interspecies homolog to rattus Trim17 (74.8 pc)
    homolog to murine Trim17 (76.5 pc)
    Homologene
    FAMILY
  • B box family
  • RBCC (TRIM family)
  • TRIM/RBCC protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potential transcriptional regulation of spermatogenesis
  • may have an E3-ubiquitin ligase activity
  • one of the critical E3 ubiquitin ligases involved in the control of neuronal apoptosis upstream of mitochondria
  • its E3 activity is both necessary and sufficient for the initiation of neuronal apoptosis
  • causes protein degradation of ZWINT and negatively regulates cell proliferation
  • crucial E3 ubiquitin ligase that is necessary and sufficient for neuronal apoptosis
  • despite its ability to inhibit certain types of selective autophagy, TRIM17 promoted the removal of midbodies, remnants of the cell division machinery that are known autophagy targets
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ions Zn2+
    • protein
  • interacting with TRIM44
  • interacted with ZWINT and overexpression of TRIM17 caused down-regulation of protein levels of ZWINT in mammalian cells
  • TRIM17 binds preferentially SUMOylated forms of NFATC3
  • TRIM17 also inhibited NFATC4 nuclear translocation and activity
  • NFATC3 binds to the promoter of the TRIM17 gene together with JUN
  • TRIM17 stabilizes BCL2A1 by blocking TRIM28 from binding and ubiquitinating BCL2A1, and GSK3B is involved in the phosphorylation-mediated inhibition of BCL2A1 degradation
  • TRIM17 decreases the TRIM41-mediated degradation of ZSCAN21
  • TRIM17 and TRIM41 modulate SNCA expression by regulating ZSCAN21
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS