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FLASH GENE
Symbol TRIM16 contributors: np/mct - updated : 09-02-2011
HGNC name tripartite motif-containing 16
HGNC id 17241
Location 17p12      Physical location : 15.531.280 - 15.586.193
Synonym name estrogen-responsive B box protein
Synonym symbol(s) EBBP, DKFZp434O1826
DNA
TYPE functioning gene
STRUCTURE 54.91 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388339 17 similar to ribosomal protein LOC390765 17 similar to 60S ribosomal protein L23a LOC388340 17 LOC388340 PMP22 17p12-p11.2 peripheral myelin protein 22 TEKT3 17p12 tektin 3 FLJ36674 17p11.2 hypothetical protein FLJ36674 LOC201158 17p11.2 similar to CGI-148 protein C17orf1A 17p11 chromosome 17 open reading frame 1A CDRT1 17p12 CMT1A duplicated region transcript 1 TRIM16 17p11.2 tripartite motif-containing 16 ZNF286 17p11.2 zinc finger protein 286 LOC246719 17p11.2 ubiquitin carrier protein E2-EPF pseudogene MGC51025 7p11.2 hypothetical protein MGC51025 LOC147151 17p11.2 hypothetical LOC147151 IL6STP 17p11.2 interleukin 6 signal transducer (gp130, oncostatin M receptor) pseudogene MEIS3 17p11.1 Meis1, myeloid ecotropic viral integration site 1 homolog 3 (mouse) ADORA2B 17p11.2 adenosine A2b receptor FLJ20343 17p11.2 hypothetical protein FLJ20343 NCOR1 17-p11.2 nuclear receptor co-repressor 1 PIGL 17p12-p11.2 phosphatidylinositol glycan, class L p30 17p11.2 nuclear protein p30 UBB 17p12-p11.1 ubiquitin B TRPV2 17p11.2 transient receptor potential cation channel, subfamily V, member 2 MGC40157 17p11.2 hypothetical protein MGC40157 LOC388341 17 similar to Hypothetical protein LOC192976 ZNF287 17p11.2 zinc finger protein 287 LOC284045 17p11.2 hypothetical gene supported by NM_006275; BC006832; U30828; U30829; U30883 KIAA1349 17p11.2 KIAA1349 protein LOC390766 17 similar to Ribonuclease H1 (RNase H1) (Ribonuclease H type II) LOC147226 17p11.2 similar to yeast Upf3, variant A pseudogene LOC252841 17p11.2 signal recognition particle 68kD pseudogene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2920 - 564 - 2010 16636064
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Skin/Tegumentskin     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
Skin/Tegumentkeratinocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • missing the RING finger domain
  • B box domain type 1 and type 2
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM), required for TRIM16 and E2F1 interaction
  • two zinc binding domains
  • RFP-like domain, an important protein-binding domain
  • a C-terminal Ret finger, or B30.2 (SPRY), domain of unknown function
  • HOMOLOGY
    Homologene
    FAMILY
  • RING-B box-coiled-coil/TRIM protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • predominantly cytoplasmic localization
  • predominantly found in the cytoplasm and to a lesser extent in the nucleus
  • basic FUNCTION
  • playing a role in the regulation of keratinocyte differentiation
  • has histone acetyltransferase activity, which is required for the retinoid-induced retinoic acid (RA) receptor beta2 transcriptional response and growth inhibition in retinoid-treated cancer cells
  • role in innate immunity by enhancing the alternative secretion pathway of IL1B
  • reduced cell motility and this required downregulation of vimentin
  • acts as a tumour suppressor, affecting neuritic differentiation, cell migration and replication through interactions with cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds DNA
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
    cell & other
    REGULATION
    inhibited by estrogen responsive,downregulated by tamoxifen
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in retinoid-resistant cancer cells induced retinoid sensitivity
    tumoral     --low  
    in poorly differentiated neuroblastoma tumour cells
    constitutional     --low  
    in a hyperproliferative epithelium is required to maintain the cells in a non-differentiated stage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    important target for future differentiation therapy development in cancer
    cancer  
    agents that increase the cytoplasmic and/or nuclear levels of TRIM16 might be expected to inhibit cell migration and replication, respectively, and, moreover, enhance the anticancer effects of differentiation therapies, such as retinoids
    ANIMAL & CELL MODELS