Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TRIM15 contributors: KTN/npt - updated : 10-02-2009
HGNC name tripartite motif-containing 15
HGNC id 16284
Location 6p21.33      Physical location : 1.371.201 - 30.140.466
Synonym name
  • zinc finger protein 178
  • zinc finger protein B7
  • RING finger protein 93
    • Synonym symbol(s) RNF93, ZNFB7, ZNF178
    DNA
    TYPE functioning gene
    STRUCTURE 9.49 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D6S464 - D6S306 - TRIM15 - D6S273 - D6S1615 - cen
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2241 52 465 - Reymond (2001)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING zinc finger
  • a B-box domain
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C terminal B30-2/SPRY domain
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Trim15 (76.3 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potentially identifying specific cell compartments
  • acting as an ubiquitin-protein ligase
  • contributing to the endogenous restriction of retroviruses in cells (Uchil 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS