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FLASH GENE
Symbol TRIM14 contributors: mct - updated : 07-11-2017
HGNC name tripartite motif-containing 14
HGNC id 16283
Location 9q22.33      Physical location : 100.831.568 - 100.881.488
Synonym name PU1 binding protein
Synonym symbol(s) KIAA0129, PUB
DNA
TYPE anonymous DNA segment
STRUCTURE 47.40 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 4629 49 442 - 2001 11331580
  • isoform alpha-V1
  • 7 splicing 1654 49 442 - 2001 11331580
  • isoform alpha-V2
  • alternatively spliced 3'utr
  • - - 1790 49 442 - 2001 11331580
    alternative exon in 3'utr
    - - 3690 28 253 - 2001 11331580
    different C terminus
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
     stomach   highly
    Lymphoid/Immunelymph node    
     thymus    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a tripartite motif, consisting of RING finger
  • B-box zinc finger
  • coiled-coil region
  • B30.2-like domain
  • HOMOLOGY
    interspecies homolog to murine Pub
    Homologene
    FAMILY B box family, RBCC (TRIM family)
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text
  • cytoplasmic speckles
  • localizes to the outer membrane of mitochondria
  • basic FUNCTION
  • may be important in regulating the transcriptional activity of SPI1
  • is a mediator in the immune response against viral infection
  • is a component of the mitochondrial antiviral immunity that facilitates the immune response mediated by retinoic acid-inducible gene-I-like receptors
  • TRIM14 functions as an oncogene by upregulating the AKT1 signaling pathway in osteosarcoma cells
  • is a mitochondrial adaptor that facilitates innate immune signaling
  • mitochondrial adaptor that promotes innate immune signaling and plays important roles in antiviral defense
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WRNIP-TRIM14-PPP6C mitochondrial signalosome required for DDX58-mediated innate antiviral immunity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRIM14 interacts with MAVS
  • TRIM14 inhibits CGAS degradation mediated by selective autophagy receptor SQSTM1 to promote innate immune responses
  • RNF125 is a negative regulator of TRIM14 in the innate antiviral immune response
  • IRF1 and IRF2 bind to the TRIM14 promoter and activate transcription of TRIM14
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    promotes the progression of Tongue squamous cells carcinoma (TSCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhead and neck 
    might represent a novel therapeutic target for the treatment of Tongue squamous cells carcinoma (TSCC)
    ANIMAL & CELL MODELS