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FLASH GENE
Symbol TRIM13 contributors: mct - updated : 23-03-2016
HGNC name ret finger protein 2
HGNC id 9976
Location 13q14.3      Physical location : 50.571.142 - 50.592.603
Synonym name
  • tripartite motif protein 13
  • candidate tumor suppressor involved in B-CLL
  • Synonym symbol(s) CAR, LEU5, RFP2, DLEU5, RNF77
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 21.00 kb     4 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    motif repetitive sequence
    text structure promoter area is TATA-less, highly enriched in G and C nucleotides, and contains multiple quadruplex forming GGGGA-repeats
    MAPPING cloned Y linked N status confirmed
    Map see TSG13D
    RNA
    TRANSCRIPTS type messenger
    text alternatively spliced to produce either several monocistronic teranscripts or a putative bicistronic transcript
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 6776 47 407 - Kapanadze, Lerner (2007)
    alternative splicing in the 5'UTR
    2 - 6861 47 407 - Kapanadze, Lerner (2007)
    2 - 7311 - 407 - Lerner (2007)
    4 - 6975 - 410 - Lerner (2007)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING zinc finger necessary for Ubiquitin ligase activity (ubiquitin ligase activity is dependent on an intact RING domain)(Lerner 2007)
  • a B-box type-2 domain
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a transmembrane domain
  • C-terminal transmembrane domain indispensable for its localization to the ER and colocalizes with several ER-resident proteins (Lerner 2007)
  • conjugated MetalloP
    HOMOLOGY
    intraspecies homolog to BRCA1,MID1
    Homologene
    FAMILY
  • C-XI TRIM family
  • B box family, RBCC(TRIM family)
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in B-cell differentiation
  • unstable protein with auto-polyubiquitination activity implying that TRIM13 acts as a RING E3 ubiquitin ligase (Lerner 2007)
  • CELLULAR PROCESS nucleotide, transcription
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text embryogenesis,morphogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with p62/SQSTM1 and co-localizes with ZFYVE1
  • cell & other
    REGULATION
    Other regulated by DLEU2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in B cell chronic lymphocytic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS