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FLASH GENE
Symbol TRIM11 contributors: mct - updated : 16-06-2014
HGNC name tripartite motif-containing 11
HGNC id 16281
Location 1q42.13      Physical location : 228.581.378 - 228.594.517
Synonym symbol(s) BIA1, RNF92
EC.number 6.3.2.-
DNA
TYPE functioning gene
STRUCTURE 13.14 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MGC15634 1q42.13 hypothetical protein MGC15634 FLJ12517 1q42.13 hypothetical protein FLJ12517 IMAGE3451454 1q42.13 SVAP1 protein MPN2 1q42.13 marapsin 2 WNT9A 1q42 wingless-type MMTV integration site family, member 9A LOC340346 1q42.13 hypothetical gene supported by AK093729; AK096776; AL117642 LOC391173 1 similar to capicua homolog WNT3A 1q42 wingless-type MMTV integration site family, member 3A DKFZp434C0923 1q42.13 hypothetical protein DKFZp434C0923 ARF1 1q42 ADP-ribosylation factor 1 C1orf35 1q42.13 chromosome 1 open reading frame 35 MRPL55 1p36.3 mitochondrial ribosomal protein L55 LOC391174 1 similar to hypothetical protein FLJ22875 GUK1 1q32-q41 guanylate kinase 1 GJA12 1q41-q42 gap junction protein, alpha 12, 47kDa LOC200205 1q42.13 hypothetical protein LOC200205 FLJ14124 1q42.13 hypothetical protein FLJ14124 KIAA1639 1q42.13 KIAA1639 protein TRIM11 1q42.13 tripartite motif-containing 11 TRIM17 1q42 tripartite motif-containing 17 HIST3H3 1q42 histone 3, H3 LOC391175 1 similar to 60S ribosomal protein L23a HIST3H2A 1q42.13 histone 3, H2a HIST3H2BB 1q42.13 histone 3, H2bb HIST3H2BA 1 histone 3, H2ba LOC149603 1q42.13 hypothetical protein LOC149603 FLJ31401 1q42.13 hypothetical protein FLJ31401 LOC388750 1 similar to Ferritin heavy chain (Ferritin H subunit) ARHU 1q42.11-q42.3 ras homolog gene family, member U LOC388751 1 LOC388751
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2715 - 468 - 2008 1883647
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   moderately
Lymphoid/Immunespleen   moderately
 thymus   moderately
Reproductivefemale systembreastmammary gland moderately
 female systemovary  moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RING zinc finger, B box domain type 1 and type 2, linked to a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • two zinc binding domains and a C terminal B30.2/SPRY domain, required for the interaction with PHOX2B
  • a RFP-like domain
  • a RING domain, B-boxes, a coiled-coil domain, and the
  • mono polymer homomer , polymer
    HOMOLOGY
    interspecies homolog to rattus Trim11 (86.87 pc)
    homolog to murine Trim11 (89.72 pc)
    Homologene
    FAMILY
  • B box family, RBCC (TRIM family)
  • C-IV TRIM family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • identifying specific cell compartments
  • playing a potential role in the specification of noradrenergic phenotype by interaction with PHOX2B
  • acting as a E3 ubiquitin ligase (Ozato 2008)
  • contributing to the endogenous restriction of retroviruses in cells (Uchil 2008)
  • is a novel modifier of mutant PHOX2B toxicity
  • involved in the development of the central nervous system
  • has an oncogenic function mediated through the EGFR signaling pathway
  • promotes proliferation, invasion, migration and glial tumor growth
  • TRIM11 inhibits DDX58-mediated IFNB1 production by targeting the TBK1 signaling complex (PMID;
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PHOX2B interacting protein
  • autoregulatory feedback loop between TRIM11 and PAX6 maintains a balance between the levels of PAXx6 and TRIM11 proteins in cortical progenitors, having an essential role for the PAX6-dependent neurogenesis
  • TRIM11 plays a critical role in the clearance of mutant PHOX2B through the proteasome
  • is a novel negative regulator of IFNB1 production
  • TRIM11 and TBK1, a key kinase that phosphorylates IRF3 in the DDX58 pathway, interacted with each other through CC and CC2 domain, respectively (PMID;
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in high-grade gliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurology  
    represents a potential therapeutic target for congenital central hypoventilation syndrome
    ANIMAL & CELL MODELS