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FLASH GENE
Symbol TRIM10 contributors: KTN/npt - updated : 10-02-2009
HGNC name tripartite motif-containing 10
HGNC id 10072
Location 6p21.33      Physical location : 1.359.960 - 30.128.711
Synonym name
  • ring finger protein 9
  • hematopoietic RING finger 1
  • B30-RING finger protein
  • Synonym symbol(s) RFB30, RFB30H, HERF1, RNF9, MGC141979
    DNA
    TYPE functioning gene
    STRUCTURE 8.99 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D6S464 - D6S306 - TRIM10 - D6S273 - D6S1615 - cen
    Authors UCSC (2009)
    Physical map
    3.8-1.2 6p21.3 3.8-1.2 pseudogene P5-02 HLA-J 6p21.3 major histocompatibility complex, class I, J (pseudogene) ETF1P1 6p21.3 eukaryotic translation termination factor 1 pseudogene 1 C6orf12 6p22.1 chromosome 6 open reading frame 12 ZNRD1 6p21.3 zinc ribbon domain containing, 1 PPP1R11 6p21.3 protein phosphatase 1, regulatory (inhibitor) subunit 11 RNF39 6p21.3 ring finger protein 39 TRIM31 6p21.3 tripartite motif-containing 31 TRIM40 6p21.31 tripartite motif-containing 40 TRIM10 6p21.3 tripartite motif-containing 10 TRIM15 6p21.3 tripartite motif-containing 15 TRIM26 6p21.3 tripartite motif-containing 26 HLA-L 6p21.3 major histocompatibility complex, class I, L
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 3572 54.9 481 - Goei (1994)
    8 splicing 3033 45.1 395 - Goei (1994)
  • using an alternate splice site producing the introduction of a 539 nt intron between a 3' penultimate and 3' terminal exon compared to the 3' terminal exon of variant 1
  • resulting in a frameshift and introduction of a novel stop codon
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cell lineage erythroid cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING zinc finger
  • a B-box domain
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C-terminal B30.2/SPRY domain
  • HOMOLOGY
    interspecies homolog to rattus Trim10 (83.3 pc)
    homolog to murine Trim10 (84 pc)
    intraspecies homolog to RORET, ZNF173
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role in terminal differentiation of erythroid cells
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS