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FLASH GENE

Symbol

TRIM10

contributors: KTN/npt - updated : 10-02-2009

HGNC name	tripartite motif-containing 10
HGNC id	10072

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.33      Physical location : 1.359.960 - 30.128.711
Synonym name	ring finger protein 9
	hematopoietic RING finger 1
	B30-RING finger protein
Synonym symbol(s)	RFB30, RFB30H, HERF1, RNF9, MGC141979

DNA

TYPE	functioning gene
STRUCTURE	8.99 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - D6S464 - D6S306 - TRIM10 - D6S273 - D6S1615 - cen
Authors	UCSC (2009)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 7 splicing 3572 54.9 481 - Goei (1994) variant 2 8 splicing 3033 45.1 395 - Goei (1994) using an alternate splice site producing the introduction of a 539 nt intron between a 3' penultimate and 3' terminal exon compared to the 3' terminal exon of variant 1 resulting in a frameshift and introduction of a novel stop codon

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cell lineage	erythroid cells
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal RING zinc finger
	a B-box domain
	a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
	a C-terminal B30.2/SPRY domain

HOMOLOGY

interspecies	homolog to rattus Trim10 (83.3 pc)
	homolog to murine Trim10 (84 pc)

intraspecies

homolog to RORET, ZNF173

Homologene

FAMILY	TRIM/RBCC family
	C-IV TRIM family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION

playing a role in terminal differentiation of erythroid cells

CELLULAR PROCESS	cell life, differentiation
	nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS