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FLASH GENE
Symbol TRIL contributors: mct/pgu - updated : 02-02-2013
HGNC name TLR4 interactor with leucine-rich repeats
HGNC id 22200
Location 7p14.3      Physical location : 28.992.975 - 28.998.029
Genatlas name TLR4 interactor with leucine-rich repeats
Synonym name
  • hypothetical protein LOC9865
  • cDNA sequence, expressed in brain, 85kDa, related to murine insuline-like IGFBP3 growth factor binding complex acid labile chain
    • Synonym symbol(s) tcag7.161, KIAA0644
    DNA
    TYPE functioning gene
    STRUCTURE 5.06 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 5056 - 811 - 2009 19710467
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineneuroendocrinepituitary   
    Lymphoid/Immunespleen    
    Nervousbrain   highly Homo sapiensAdult
     spinal cord    
    Reproductivefemale systembreastmammary gland  
     female systemovary  highly
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • 13 leucine-rich repeats
  • a fibronectin domain
  • a single transmembrane spanning region
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    text
  • co-localizes with the endosomal compartment
    • basic FUNCTION
  • related to murine insuline-like IGFBP3 growth factor binding complex acid labile chain
  • may have particular relevance for the functional role of TLR4 in brain
  • modulator of TLR4 signaling showing high expression in the brain
  • role for TRIL in TLR3 signaling and endosomal TLR4 signaling
  • potentially important role in inflammatory pathways within the central nervous system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the TLR4 complex
  • important component in endosomal signaling by TLR3, TLR4
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TLR4 and LPS
  • interacted with TLR3, and this interaction was enhanced following poly(I:C) stimulation
  • TLR3 engages the adaptor molecule TRIF in order to activate the production of type I interferons
  • both TRIL and CD14 carry out similar functions, and TRIL may compensate for CD14 in the brain
    • cell & other
    REGULATION
    induced by LPS in an number of cell types
    induced by the TLR3 ligand poly(I:C)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the CNS of patients suffering from amyotrophic lateral sclerosis, a fatal neurodegenerative disease that is characterized by weakness resulting from loss of motor neurons
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS