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FLASH GENE
Symbol TRIAP1 contributors: mct - updated : 06-07-2016
HGNC name TP53 regulated inhibitor of apoptosis 1
HGNC id 26937
Location 12q24.31      Physical location : 120.881.764 - 120.884.215
Synonym name
  • mitochondrial distribution and morphology 35 homolog
  • TP53-inducible cell-survival factor
  • Synonym symbol(s) HSPC132, MDM35, P53CSV, WF-1
    DNA
    TYPE functioning gene
    STRUCTURE 2.45 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1196 9 76 - 2013 23931759
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a twin CX9C sequence motif that is predicted to form two disulphide bonds within the oxidising environment of mitochondrial IMS
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • is a novel apoptosis inhibitor that binds HSP70 in the cytoplasm and blocks the formation of the apoptosome and CASP9 activation
  • contributes to the maintenance of cardiolipin (CL) levels in the inner mitochondrial membrane of human cells, thereby sequestering cytochrome c and stalling apoptosis
  • modulates apoptotic pathways preventing the formation of the apoptosome complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex of TRIAP1 (p53CSV) and PRELID1 in the mitochondrial intermembrane space (IMS), which ensures the accumulation of cardiolipin in mitochondria
  • PRELID3A with its mitochondrial chaperones (TRIAP1) represent a unique heterodimeric lipid transfer system that is evolutionary conserved from yeast to man
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRIAP1 is a specific repressor of CDKN1A whose depletion slows down cell-cycle progression
  • TRIAP1/PRELID1 complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • represents a novel marker for drug resistance in breast cancer cells
  • Therapy target
    ANIMAL & CELL MODELS