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Symbol TRG@ contributors: - updated : 03-07-2006
HGNC name T cell receptor gamma locus
HGNC id 12271
Location 7p15-p14      Physical location : -
Synonym name
  • T cell receptor gamma locus, including from the telomere to the centromere, a duplicated J-C cluster upstream of a TRGV@ cluster, including 14 genes
    • Synonym symbol(s) TCRG@
    DNA
    TYPE cluster
    MAPPING cloned   linked   status confirmed
    Map cen - TRGV1 - TRGV2 - TRGV3 - TRGV4 - TRGV5 - TRGV5P - TRGV6 - TRGV7 - TRGV8 - TRGVA - TRGV9 - TRGV10 ,TRGVB - TRGV11 - TRGJP1 - TRGJP - TRGJ1 - TRGC1 -TRGJP2 - TRGC2 - pter
    Authors Lefranc (03)
    RNA
    TRANSCRIPTS type
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoietic     
    Lymphoid/Immunelymph node    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    digestif 
    Lymphoid/ImmuneT cell
    skin tegument 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text thymocyte
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a large N-terminal extracellular segment, folded into two Ig-like domains with both ends joined by a disulfide bond, one variable forming the antigen-binding site with the delta domain, one constant
  • a transmembrane segment (TM1)
  • a short cytoplasmic tail
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY unknown/unspecified , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION encoding the T cell receptor, gamma repertoire
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text cellular immunity
    PATHWAY
    metabolism
    signaling
    a component component of the T cell receptor, type 1, which is a disulfide bound heterodimer of a gamma and a delta chain, associated to the CD3 complex
    INTERACTION
    DNA
    RNA
    small molecule other,
    binding the fragmented (bactrerial) antigens in a MHC restricted way
    protein
    cell & other antigen presentingcell
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS