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FLASH GENE
Symbol TREX2 contributors: mct/npt - updated : 08-09-2009
HGNC name three prime repair exonuclease 2
HGNC id 12270
Location Xq28      Physical location : 152.710.178 - 152.711.945
Synonym name 3'-5' exonuclease TREX2
EC.number 3.1.11.2
DNA
TYPE functioning gene
STRUCTURE 1.77 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
alternative promoter
MAPPING cloned Y linked N status provisional
Physical map
MAGEA3 Xq28 melanoma antigen, family A, 3 MAGEA6 Xq28 melanoma antigen, family A, 6 psMAGEA Xq28 melanoma antigen pseudogene, family A CETN2 Xq28 centrin, EF-hand protein, 2 H105E3 Xq28 centrin, EF-hand protein, 2 ZNF185 Xq28 zinc finger protein 185 (LIM domain) PNMA5 Xq28 paraneoplastic antigen like 5 PNMA3 Xq28 paraneoplastic antigen MA3 MGC15827 Xq28 hypothetical protein MGC15827 MAGEA1 Xq28 melanoma antigen, family A, 1 (directs expression of antigen MZ2-E) LOC139046 Xq28 similar to hypothetical protein MGC15827 ZNF275 Xq28 zinc finger protein 275 LOC392559 X similar to hypothetical protein MGC15827 LOC139735 Xq28 similar to zinc finger protein 92 TREX2 Xq28 three prime repair exonuclease 2 LOC389904 X similar to Extracellular matrix protein 2 precursor (Matrix glycoprotein SC1/ECM2) BGN Xq28 biglycan ATP2B3 Xq28 ATPase, Ca++ transporting, plasma membrane 3 MGC29729 Xq28 hypothetical protein MGC29729 LOC340598 Xq28 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) DUSP9 Xq28 dual specificity phosphatase 9 LOC347544 Xq28 similar to ribosomal protein L18a; 60S ribosomal protein L18a MGC45419 Xq28 Similar to calcium/calmodulin-dependent protein kinase 1, beta SLC6A8 Xq28 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 BCAP31 Xq28 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 ABCD1 Xq28 ATP-binding cassette, sub-family D (ALD), member 1 PLXNB3 Xq28 plexin B3 STK23 Xq28 serine/threonine kinase 23 IDH3G Xq28 isocitrate dehydrogenase 3 (NAD+) gamma SSR4 Xq28 signal sequence receptor, delta (translocon-associated protein delta) KIAA1444 Xq28 LU1 protein HCP45 Xq28 cytochrome c, somatic pseudogene L1CAM Xq28 L1 cell adhesion molecule (hydrocephalus, stenosis of aqueduct of Sylvius 1, MASA (mental retardation, aphasia, shuffling gait and adducted thumbs) syndrome, spastic paraplegia 1) AVPR2 Xq28 arginine vasopressin receptor 2 (nephrogenic diabetes insipidus) ARHGAP4 Xq28 Rho GTPase activating protein 4
RNA
TRANSCRIPTS type messenger
text alternative promoter, varied sites for 3' cleavage
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2260 - 236 - Esposito, Hahn, Chen (2007)
2 splicing 1255 - 236 - Chen (2007)
- splicing 2116 - 236 - Chen (2007)
- splicing 1982 - 279 - Chen (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
cell cycle     cell cycle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three conserved exonuclease motifs with an HXAXXD sequence in the third motif
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Trex2
    Homologene
    FAMILY
  • exonuclease superfamily
  • TREX family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • catalyzing excision of nucleoside monophosphates from 3' termini of DNA (exonuclease)
  • may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity
  • may play a role in DNA repair
  • nonprocessive enzyme that removes nucleotides at DNA 3' termini
  • plays an important function during DNA metabolism and cellular proliferation
  • undergoes a conformational change in the active site upon DNA binding including ordering of active site residues and a shift of an active site helix (de Silva 2009)
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA TREX2–DNA complex has revealed new information about the interaction of this enzyme with substrate (De Silva 2009)
    RNA
    small molecule
    protein
  • with UCH37
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS