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FLASH GENE
Symbol TREML1 contributors: mct - updated : 23-09-2015
HGNC name triggering receptor expressed on myeloid cells-like 1
HGNC id 20434
Location 6p21.1      Physical location : 41.117.343 - 41.122.070
Synonym name TREM-like transcript 1
Synonym symbol(s) TLT-1, dJ238O23.3, TLT1, GLTL1825, PRO3438
DNA
TYPE functioning gene
STRUCTURE 5.09 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1023 - 200 - 2012 22761415
5 - 1303 - 199 - 2012 22761415
6 - 1356 - 311 - 2012 22761415
- - - - 202 localized to the cytoplasmic membrane in osteoclast precursor cells 2012 22761415
  • soluble isoform
  • very short extracellular immunoglobulin domain
  • negatively regulates osteoclastogenesis
  • physically interacted with TREM2, the ITAM-associated co-stimulatory receptor essential for osteoclast differentiation
  • modulates calcium oscillations
  • regulates likely the basal TREM2 signaling
  • in sepsis, significantly elevated levels of sTLT-1 in the
    • blood
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte Homo sapiens
    Blood/Hematopoieticplatelet Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    Skeletonosteoclast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extracellular Ig domain
  • a proline-rich region
  • contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain capable of recruiting protein-tyrosine phosphatases
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY TREM family
    CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • abundant platelet-specific, type I transmembrane receptor
  • membrane protein receptor found in alpha-granules of platelets and megakaryocytes
    • basic FUNCTION
  • may regulate the signaling of the TREM family receptors (TLT-1)
  • type 1 single Ig domain orphan receptor specific to platelet and megakaryocyte alpha-granules, relocating to the platelet surface upon platelet stimulation
  • plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury
  • during inflammation, soluble isoform may mediate hemostasis by enhancing actin polymerization, resulting in increased platelet aggregation and adherence to the endothelium
  • facilitate platelet aggregation through binding to fibrinogen
  • soluble TREML1 is important in regulating leukocyte activation during other noninfectious inflammatory disorders
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    therapeutic modulation of TLT-1-mediated effects may provide clinical benefit to patients with hypercoagulatory conditions, including those associated with inflammation
    ANIMAL & CELL MODELS
  • Tlt-1 null mice exhibit deficiency in platelet aggregation and are susceptible to lipopolysaccharide-induced septic shock
  • platelets of Treml1-/- mice failed to aggregate efficiently, extending tail-bleeding times