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FLASH GENE
Symbol TREM1 contributors: mct - updated : 29-06-2012
HGNC name triggering receptor expressed on myeloid cells 1
HGNC id 17760
Location 6p21.1      Physical location : 41.243.711 - 41.254.457
Synonym symbol(s) Trem-1, CD354
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text component of a cluster with TREM2 and NCR2
STRUCTURE 11.46 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1440 - 150 - 2003 12645956
4 - 1633 - 234 - 2003 12645956
3 - 2102 - 225 - 2003 12645956
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte Homo sapiens
Blood/Hematopoieticneutrophil Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a hydrophobic signal peptide
  • an extracellular region
  • a single immunoglobulin V-type domain
  • three potential N-glycosylation sites
  • a transmembrane stretch with a charged lysine residue and a 5-amino acid cytoplasmic tail with no signaling motifs
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to C.elegans Y119C1B.5
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • playing a role in acute inflammation
  • mediating activation of neutrophils and monocytes
  • engagement of TREM1 triggers secretion of IL8, respiratory burst and phagocytosis
  • induction of monocyte chemotactic protein-1, and TNF-alpha which induce neutrophil degranulation
  • play a role in the innate immune response against intra-amniotic infection
  • its expression in response to TLR ligands occurs secondary to downstream signaling events and the presence of TLR is necessary for the expression of TREM1 in response to their specific ligands
  • involved in the innate inflammatory response to microbial infections
  • hypoxia-inducible gene in mature dendritic cells
  • activating receptor expressed on neutrophils and monocytes that amplifies inflammation induced by stimulation of pattern-recognition receptors
  • activating receptor on inflammatory cells upregulated by microbial products
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text
  • innate immunity, humoral defense mechanism
  • PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component . associating with TREM2 and CLECSF5/MDL1 to form a signaling pathway in matre differentiated myelomonocytic
    cells
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TREM1 and TLR interact creating synergistic activation in polymorphonuclear neutrophils (PMN)
  • associated with TYROBP in hypoxic mature dendritic cells, and its engagement elicited TYROBP-linked signaling, resulting in MAPK3, AKT1, and NFKBIA phosphorylation
  • interacts with the toll-like receptor 4 (TLR4) receptor complex, or is a component of this complex, and some of the biological effects of TREM1 may be due to its interaction with the TLR4/LPS-receptor complex
  • interacting with BTK, a positive regulator in the ITAM-mediated TREM1/TYROBP pathway, suggesting its implication in inflammatory processes
  • cell & other
    REGULATION
    induced by stimulation with lipopolysaccharide (LPS),gram-negative bacteria and fungi
    inhibited by prostaglandins (by PGD2 and PGJ2) in macrophages
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in infectious exacerbations of chronic obstructive pulmonary disease
    constitutional     --over  
    in biological fluids and tissues infected by Gram (+) and Gram (-) bacteria and fungi, amplifies the production of pro-inflammatory cytokines and chemokines
    constitutional     --over  
    on monocytes is associated with both infectious and noninfectious inflammatory processes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum TREM1 level could be a potential marker for the assessment of disease activity of intestinal Behcet disease
  • Therapy target
    ANIMAL & CELL MODELS