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FLASH GENE

Symbol

TRB@

contributors: - updated : 26-01-2004

HGNC name	T cell receptor beta locus
HGNC id	12155

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q34      Physical location : -
Synonym name	T cell receptor beta region, containing 71 variable genes and two clusters of diversity, joining and constant segments, rearranged during thymocyte ontogenesis to produce the beta subunit of the TCR-2 (alpha-beta) T cell receptor
Synonym symbol(s)	TCRB

DNA

TYPE	cluster
SPECIAL FEATURE	arranged in tandem
text	also containing six trypsinogen genes embedded in the TRB@ (see map and references)
STRUCTURE	620.00 kb     0 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - PRSS3 - TRAV@ -PRSS1 - TRY6 - TRY7 - PRSS2 - TRBV30 - qter
Authors	Rowen (96), Lefranc (03)

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Lymphoid/Immune lymph node

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text

thymocyte

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a large N-terminal extracellular segment, folded into two Ig-like . domains with both ends joined by a disulfide bond, one variable and forming the antigen-binding site, one constant
	a transmembrane segment (TM1)
	a short cytoplasmic tail

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

encoding the T cell receptor, beta chain repertoire

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	cellular immunity

PATHWAY

metabolism

signaling

a component

component of the T cell receptor, type 2, which is a disulfide bound heterodimer of an alpha and a beta chain, associated to the CD3 complex

INTERACTION

DNA

RNA

small molecule	other,
	binding the fragmented antigens, in a MHC restricted way

protein

cell & other

antigen presenting cell

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS