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FLASH GENE
Symbol TRAV@ contributors: - updated : 18-02-2006
Location 14q11.2      Physical location : -
Genatlas name T cell receptor alpha, variable region, containing at least 56 genes, 45 functioning, 10 pseudogenes and one like-sequence (open reading frame ORF, according to MP LEFRANC (IMGT), see reference), that can be grouped into 32 subfamilies
Synonym symbol(s) TCRAV@
DNA
TYPE cluster
MAPPING cloned Y linked N status confirmed
Map see TRA@
regionally located located at the centromeric end of the TRA@ cluster
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text thymocyte
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a variable alpha domain consisting of about 110 AAs folded into a Ig-like domain with both ends joined by a disulfide bond
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION antigen binding
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text cellular immunity
    PATHWAY
    metabolism
    signaling
    a component component of the T cell receptor, type 2, which is a disulfide bound heterodimer af an alpha and a beta chain
    INTERACTION
    DNA
    RNA
    small molecule other,
    binding the fragmented antigens in a MHC restricted way
    protein forming the antigen binding site with a TRBV protein
    cell & other antigen presenting cell
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS