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FLASH GENE
Symbol TRAV12-1 contributors: - updated : 24-01-2004
HGNC name T cell receptor alpha variable 12-1
HGNC id 12105
Location 14q11.2      Physical location : -
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 0.00 kb     1 Exon(s)
MAPPING cloned Y linked N status confirmed
Physical map
TRAV1-1 14q11.2 T cell receptor alpha variable 1-1, TRAV1-2 14q11.2 T cell receptor alpha variable 1-2 TRAV2 14q11.2 T cell receptor alpha variable 2 TRAV3 14q11.2 T cell receptor alpha variable 3 TRAV4 14q11.2 T cell receptor alpha variable 4 TRAV5 14q11.2 T cell receptor alpha variable 5 TRAV6 14q11.2 T cell receptor alpha variable 6 TRAV7 14q11.2 T cell receptor alpha variable 7 TRAV8-1 14q11.2 T cell receptor alpha variable 8-1 TRAV9-1 14q11.2 T cell receptor alpha variable 9-1 TRAV10 14q11.2 T cell receptor alpha variable 10 TRAV11 14q11.2 T cell receptor alpha variable 11 TRAV12-1 14q11.2 T cell receptor alpha variable 12-1 TRAV8-2 14q11.2 T cell receptor alpha variable 8-2 TRAV8-3 14q11.2 T cell receptor alpha variable 8-3 TRAV13-1 14q11.2 T cell receptor alpha variable 13-1 TRAV12-2 14q11.2 T cell receptor alpha variable 12-2 TRAV8-4 14q11.2 T cell receptor alpha variable 8-4 TRAV8-5 14q11.2 T cell receptor alpha variable 8-5 TRAV13-2 14q11.2 T cell receptor alpha variable 13-2 TRAV14DV4 14q11.2 T cell receptor alpha variable 14/delta variable 4, rearranged to either TRDD or TRAJ TRAV9-2 14q11.2 T cell receptor alpha variable 9-2 TRAV15 14q11.2 T cell receptor alpha variable 15 TRAV12-3 14q11.2 T cell receptor alpha variable 12-3 TRAV8-6 14q11.2 T cell receptor alpha variable 8-6 TRAV16 14q11.2 T cell receptor alpha variable 16
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text thymocyte
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a variable alpha domain of about 110 AAs, folded into a Ig-like domain with both ends joined by a disulfide bond
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION antigen binding
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text cellular immunity
    PATHWAY
    metabolism
    signaling
    a component component of the T cell receptor, type 2, which is a disulfide bound heterodimer of an alpha and a beta chain
    INTERACTION
    DNA
    RNA
    small molecule other,
    binding fragmented antigens in a MHC restricted way
    protein
  • forming wih a TRBV protein, the binding site where the antigen is presented by a MHC molecule
  • cell & other antigen presenting cells
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS