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FLASH GENE

Symbol

TRAV@

contributors: - updated : 18-02-2006

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q11.2      Physical location : -
Genatlas name	T cell receptor alpha, variable region, containing at least 56 genes, 45 functioning, 10 pseudogenes and one like-sequence (open reading frame ORF, according to MP LEFRANC (IMGT), see reference), that can be grouped into 32 subfamilies
Synonym symbol(s)	TCRAV@

DNA

TYPE

cluster

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see TRA@

regionally located

located at the centromeric end of the TRA@ cluster

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Lymphoid/Immune lymph node

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text

thymocyte

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a variable alpha domain consisting of about 110 AAs folded into a Ig-like domain with both ends joined by a disulfide bond

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

antigen binding

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	cellular immunity

PATHWAY

metabolism

signaling

a component

component of the T cell receptor, type 2, which is a disulfide bound heterodimer af an alpha and a beta chain

INTERACTION

DNA

RNA

small molecule	other,
	binding the fragmented antigens in a MHC restricted way

protein

forming the antigen binding site with a TRBV protein

cell & other

antigen presenting cell

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS