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FLASH GENE
Symbol TRAT1 contributors: npt - updated : 01-07-2002
HGNC name T cell receptor associated transmembrane adaptor 1
HGNC id 30698
Location 3q13      Physical location : 108.541.630 - 108.573.714
Synonym name T cell receptor interacting molecule
Synonym symbol(s) HSPC062, TRIM, TCRIM, pp29/30
DNA
TYPE functioning gene
STRUCTURE 32.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1695 21 186 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage T and NK cell lines
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short extracellular domain
  • a transmembrane segment (TM1)
  • a large cytoplasmic tail containing several tyrosine based signaling motifs that could be involved in SH2 mediated protein-protein interactions
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • likely involved in targeting of intracellular signaling proteins to the plasma membrane after triggering of TCR and phosphorylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating and comodulating with the TCR-CD3-zeta complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS