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FLASH GENE
Symbol TRARG1 contributors: mct/npt - updated : 22-06-2021
HGNC name trafficking regulator of GLUT4 (SLC2A4) 1
HGNC id 29592
Location 17p13.3      Physical location : -
Synonym name
  • located at seventeen-p-thirteen point three 1
  • brain endothelial cell derived gene-1
  • tumor suppressor candidate 5
  • brain endothelial cell derived gene-1
  • dispanin subfamily B member 1
  • interferon induced transmembrane protein domain containing 3
  • Synonym symbol(s) LOST1, BEC-1, TUSC5, DSPB1, IFITMD3
    DNA
    TYPE functioning gene
    STRUCTURE 21.32 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3596 19.12 177 - 2018 29787242
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousgangliasensory gangliadorsal root  
     nervecranial nerve   
    Reproductivefemale systembreastmammary gland  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebonesubchondral  
    Muscularstriatumskeletal  
    Nervouscentralwhite matter  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    not specificadipocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus is cytosolic
  • one transmembrane domain (TMD) (145-172)
  • a re-entrant loop between AAs 101 and 127
  • a short segment at the C-terminus resides in the luminal/extracellular space
  • HOMOLOGY
    interspecies ortholog to rat Bec-1
    Homologene
    FAMILY
  • CD225 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nuclear envelope
    basic FUNCTION
  • involved in response to biotic stimulus
  • involved in the differentiation
  • involved in the regulation of adipose tissues independently of UCP1
  • CD225 domain-containing, cold-repressed gene, playing an important role in maturing adipocytes (Oort 2007)
  • is a positive regulator of insulin-stimulated glucose transport in adipocytes
  • controls insulin-stimulated glucose uptake in adipocytes
  • is an adipose tissue-specific protein that enables proper protein recycling, linking the ubiquitous vesicle traffic machinery with tissue-specific insulin-mediated glucose uptake into adipose tissue
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRARG1 expression was necessary but insufficient for PPARG-mediated reversal of insulin resistance
  • TRARG1 is a PPARG target
  • cell & other
    REGULATION
    Other regulated independently of the â-adrenergic pathway in brown adipose tissue
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be considered as potential markers of breast cancer
  • Therapy target
    ANIMAL & CELL MODELS