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FLASH GENE

Symbol

TRAPPC9

contributors: mct - updated : 19-11-2013

HGNC name	trafficking protein particle complex 9
HGNC id	30832

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MRAR6 mental retardation, non-syndromic 6
Location	8q24.3      Physical location : 140.742.585 - 141.468.678
Synonym name	NIK and IKK{beta} binding protein
	IKK2 binding protein
	tularik gene 1
	TRAPP 120 kDa subunit
Synonym symbol(s)	IBP, KIAA1882, MGC4737, MGC4769, T1, IKBKBBP, MGC4737, MGC4769, NIBP, TRS120, MRT13

DNA

TYPE	functioning gene
STRUCTURE	726.09 kb     23 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031466 23 - 4472 NP_113654 140 1246 - 2005 15951441 NM_001160372 - - 4305 NP_001153844 140 1148 - 2005 15951441

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       moderately Homo sapiens   thymus       moderately Homo sapiens Nervous nerve cranial nerve     highly Homo sapiens Urinary kidney       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Homo sapiens Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

NIBP family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	enhancer of the cytokine-induced NF-(kappa)B signaling pathway
	may be a potential target for modulating the NF-(kappa)B signaling cascade in neuronal pathologies dependent upon abnormal activation of this pathway
	having an essential function in postmitotic neurons as opposed to neural progenitors
	implicated in NF-KB activation and possibly in intracellular protein trafficking

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

NFKB signaling pathway

a component

part of the TRAPPII complex that contains the mammalian homologues of yeast Trs120 and Trs130 (TRAPPC9 and TRAPPC10)

INTERACTION

DNA

RNA

small molecule

protein	physically interacts with NIK, IKK(beta), but not IKK(alpha) or IKK(gamma)
	may be a potential target for modulating the NF-(kappa)B signaling cascade in neuronal pathologies dependent upon abnormal activation of this pathway
	interacts with the nuclear factor kappaB (NF-KB)-inducing kinase (NIK) and IKB kinase complex beta
	mediates the interaction between DCTN1 and COPII vesicles at the target membrane

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRAR6

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS