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FLASH GENE
Symbol TRAPPC8 contributors: mct - updated : 07-05-2013
HGNC name trafficking protein particle complex 8
HGNC id 29169
Location 18q12.1      Physical location : -
Synonym name
  • related to C elegans Cos F46F11
  • general sporulation gene 1 homolog (S. cerevisiae)
  • protein TRS85 homolog
  • Synonym symbol(s) KIAA1012, HsT2706, TRS85, GSG1, MGC71660
    DNA
    TYPE functioning gene
    STRUCTURE 113.96 kb     29 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 6283 - 1435 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonamygdala highly
     braindiencephalonthalamus highly
     brain    
     spinal cord    
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans cosmid F46F11
    Homologene
    FAMILY
  • TRS85 family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • potentially required for nonspecific autophagy, pexophagy and the cytoplasm to vacuole targeting pathway
  • required for macroautophagy and the cytosol to vacuole transport pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of TRAPP complexes (
  • member of a third, previously unresolved, TRAPPIII complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRAPPC8 modulates autophagy and secretory trafficking and is required for TBC1D14 to bind TRAPP complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS