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FLASH GENE

Symbol

TRAPPC4

contributors: mct/npt - updated : 01-06-2010

HGNC name	trafficking protein particle complex 4
HGNC id	19943

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q23.3      Physical location : 118.889.240 - 118.894.382
Synonym name	synbindin
	TRS23 homolog
	hematopoietic stem/progenitor cell protein 172
Synonym symbol(s)	TRS23, SBDN, PTD009, CGI-104

DNA

TYPE	functioning gene
STRUCTURE	5.14 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016146 6 - 1216 NP_057230 - 219 - Ethell (2000)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Reproductive male system testis         male system prostate       Respiratory lung         Urinary bladder           kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a atypical PDZ domain (APD), structure of APD is different from the classical canonical PDZ domains by lacking the typical alphaA helix and the signature sequence Gly-Psi-Gly-Psi (Fan 2009)

HOMOLOGY

Homologene

FAMILY	TRAPP small subunits family
	TRAPPC4 subfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic,vesicle
text	cis-Golgi complex
	localized on postsynaptic membranes and intracellular vesicles within dendrites (Ethell 2000)

basic FUNCTION	may be playing role in vesicular transport from endoplasmic reticulum to Golgi
	may be having a role in postsynaptic membrane trafficking (Ethell 2000)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

one component of Transport protein particle (TRAPP) complexes (Fan 2009)

INTERACTION

DNA

RNA

small molecule

protein	physiological SDC2 ligand on dendritic spines (SDC2 induces spine formation by recruiting intracellular vesicles toward postsynaptic sites through the interaction with TRAPPC4)(Ethell 2000)
	binds SDC2 by its atypical PDZ domain (APD) and may regulate the formation of dendritic spines (Fan 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS