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FLASH GENE
Symbol TRAPPC3 contributors: mct - updated : 07-04-2011
HGNC name trafficking protein particle complex 3
HGNC id 19942
Location 1p34.2      Physical location : 36.602.174 - 36.615.067
Synonym symbol(s) BET3
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene
STRUCTURE 12.90 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1278 - 180 - 2006 16908848
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 liver    
Lymphoid/Immunelymph node    
Reproductivefemale systembreastmammary gland  
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a hydrophobic tunnel inside the protein, which is occupied by a fatty acid linked to cysteine-68
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • cis-Golgi complex
  • localizes to transitional ER structures (tERs) specialized regions of the ER from which COPII-coated vesicles emergis
  • basic FUNCTION
  • playing a key role in the targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment
  • component of the transport protein particle complex involved in vesicular trafficking to and through the Golgi complex
  • has strong self-palmitoylating activity
  • plays an important role in the organization of the TRAPP complexes in both mammalian cells and yeast
  • required for the formation of VTCs (vesicular tubular clusterse)and the transport of cargo from VTCs to the cell surfac
  • is important for the homotypic membrane fusion event, to form vesicular tubular clusters (VTCs), also called the pre-Golgi compartment (localizes to transitional ER structures (tERs) specialized regions of the ER from which COPII-coated vesicles emergis important for this homotypic membrane fusion event)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • may be part of an equivalent TRAPPI complex that regulates VTC formation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS