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FLASH GENE

Symbol

TRAPPC12

contributors: mct - updated : 20-09-2017

HGNC name	trafficking protein particle complex 12
HGNC id	24284

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	TRAPPC12D TRAPPC12 deficiency
Location	2p25.3      Physical location : -
Synonym name	tetratricopeptide repeat domain 15
Synonym symbol(s)	CGI-87, FLJ36862, TTC15, TTC-15, TRAMM

DNA

TYPE	functioning gene
STRUCTURE	100.33 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016030 12 - 2546 NP_057114 - 735 - 2011 21525244 NM_001321102 12 - 2509 NP_001308031 - 735 - 2011 21525244

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Reproductive female system uterus cervix   moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four TPR repeats

HOMOLOGY

interspecies

ortholog to murine Ttc15

Homologene

FAMILY

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,chromatin/chromosome,kinetochore
text	phosphorylated early in mitosis and dephosphorylated at the onset of anaphase

basic FUNCTION	functions in membrane trafficking between the endoplasmic reticulum (ER) and the Golgi
	in addition to playing a role in ER-Golgi transport, TRAPPC12 has been recently reported to also function in mitosis
	implicated in ER-to-Golgi trafficking at a very early stage

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

member of the TRAPP protein complex, which functions in membrane trafficking

INTERACTION

DNA

RNA

small molecule

protein	interacts with CENPE, and depletion of TRAPPC12 prevented the recruitment of CENPE to the kinetochore
	TRAPPC12, but not TRAPPC8, bound to Sec13/Sec31A tetramer but each Sec protein alone could not interact with TRAPPC12

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

TRAPPC12D

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   resulted in noncongressed chromosomes and arrested cells in mitosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS