SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,mitochondria,interspace
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| intracellular,cytoplasm,organelle,mitochondria,matrix
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,nucleus,nucleoplasm
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basic FUNCTION
| exhibiting ATPase activity |
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might play a role in protecting mitochondria against damaging stimuli via decrease of reactive oxygen species generation |
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protecting cells from oxidative stress and apoptosis |
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mitochondrial survival factor differentially expressed in localized and metastatic prostate cancer compared with normal prostate  |
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acts as a molecular chaperone to retinoblastoma protein (Rb) during cellular stress  |
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controls cell cycle activity through the tumor necrosis factor pathways  |
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mitochondrial chaperone with antioxidant and antiapoptotic functions, involved in multidrug resistance in colorectal carcinoma cells  |
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likely reduces the hypertrophy and fibrosis induced by pressure overload through blocking TAK/P38, JNK, and AKT signaling pathways  |
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is involved in the translational control of cancer cells through an attenuation of global protein synthesis  |
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controls cell migration of cancer cells in metabolic stress conditions  |
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TRAP1 is relevant in the control of the complex machinery that governs cell cycle progression and mitotic entry  |
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molecular chaperone involved in the regulation of energetic metabolism in cancer cells  |
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role of TRAP1 is to enhance or suppress oxidative phosphorylation  |
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potential TRAP1 role in triggering the alternate energy metabolism in cancer cells  |
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TRAP1 role in tumor metastasis, which is in addition to altered energy metabolism  |
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it is involved in the assembly of the electron transport chain, and it favours the switch from oxidative phosphorylation to glycolysis  |
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supports protein folding and contributes to the maintenance of mitochondrial integrity even under cellular stress  |
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cellular regulator of mitochondrial bioenergetics, redox homeostasis, oxidative stress-induced cell death, apoptosis, and unfolded protein response (UPR) in the endoplasmic reticulum (ER)  |