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FLASH GENE

Symbol

TRAP1

contributors: mct - updated : 26-01-2022

HGNC name	TNF receptor-associated protein 1
HGNC id	16264

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.3      Physical location : 3.708.038 - 3.767.598
Synonym name	tumor necrosis factor type 1, receptor associated protein
	heat shock protein 75
Synonym symbol(s)	HSP75, HSP90L, HSP 75, TRAP-1

DNA

TYPE	functioning gene
STRUCTURE	59.49 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D16S521 - MPG - HAGH - RPL3 - D16S3024 - CLCN7 - UBE2I - ZNF174 - D16S3070 - ABCA3 - CD63 - TSC2 TSC2 - D16S510 - cen
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001272049 17 - 2064 NP_001258978 - 651 - 2005 16269234 TRAP1-2 15 - 2248 62 547 testis 2005 16269234 15 exons TRAP1-3 19 - 2189 76 669 trachea 2005 16269234 19 exons TRAP1-4 13 - 2309 54 469 - 2005 16269234 13 exons TRAP1-5 18 - 2265 76 672 brain 2005 16269234 18 exons TRAP1-6 18 - 2208 76 672 placenta 2005 16269234 18 exons NM_016292 18 - 2310 NP_057376 79 704 - 2005 16269234

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver           mouth tongue     highly Endocrine pancreas         Nervous brain         Reproductive female system uterus cervix   highly   female system placenta       Respiratory lung         Urinary kidney         Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	amnion cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mitochondrial localization sequence in the N terminus

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Trap1 (88.5pc)
	homolog to rattus Trap1 (88.5pc)

Homologene

FAMILY

heat shock protein 90 (HSP90) chaperone family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,interspace
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,organelle,membrane
	intracellular,nucleus,nucleoplasm

basic FUNCTION	exhibiting ATPase activity
	might play a role in protecting mitochondria against damaging stimuli via decrease of reactive oxygen species generation
	protecting cells from oxidative stress and apoptosis
	mitochondrial survival factor differentially expressed in localized and metastatic prostate cancer compared with normal prostate
	acts as a molecular chaperone to retinoblastoma protein (Rb) during cellular stress
	controls cell cycle activity through the tumor necrosis factor pathways
	mitochondrial chaperone with antioxidant and antiapoptotic functions, involved in multidrug resistance in colorectal carcinoma cells
	likely reduces the hypertrophy and fibrosis induced by pressure overload through blocking TAK/P38, JNK, and AKT signaling pathways
	is involved in the translational control of cancer cells through an attenuation of global protein synthesis
	controls cell migration of cancer cells in metabolic stress conditions
	TRAP1 is relevant in the control of the complex machinery that governs cell cycle progression and mitotic entry
	molecular chaperone involved in the regulation of energetic metabolism in cancer cells
	role of TRAP1 is to enhance or suppress oxidative phosphorylation
	potential TRAP1 role in triggering the alternate energy metabolism in cancer cells
	TRAP1 role in tumor metastasis, which is in addition to altered energy metabolism
	it is involved in the assembly of the electron transport chain, and it favours the switch from oxidative phosphorylation to glycolysis
	supports protein folding and contributes to the maintenance of mitochondrial integrity even under cellular stress
	cellular regulator of mitochondrial bioenergetics, redox homeostasis, oxidative stress-induced cell death, apoptosis, and unfolded protein response (UPR) in the endoplasmic reticulum (ER)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein	binding to the intracellular domain of tumor necrosis factor type 1 receptor
	binding to RB1
	interacting with cyclophilin D and negatively regulating mitochondrial cell death
	Sorcin (SI) is a new TRAP1 interactor
	a functional role of TRAP1 in maintaining mitochondrial integrity downstream of PINK1 and complex I deficits but parallel to or upstream of Parkin

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   prevented cardiac hypertrophy and fibrosis tumoral     --over   in several cancers, such as glioblastoma, colon, breast, prostate and lung cancers, often associated with drug resistance tumoral     --low   in specific tumors, such as ovarian, bladder and renal cancers, correlated with the worst prognoses and chemoresistance constitutional germinal mutation       autoinflammatory disease might be enhanced by bi-allelic mutations

Susceptibility

Variant & Polymorphism

Candidate gene	potential of TRAP1 inhibitors as neuroprotective drugs
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate targeting the TRAP1 pathway with Gamitrinibs could be explored as novel molecular therapy in patients with advanced prostate cancer cancer     targeting TRAP1 constitutes likely a new antitumor approach cancer endocrine thyroid TRAP1 inhibition may be regarded as potential strategy to target specific features of thyroid carcinoma (TC), cell proliferation and resistance to apoptosis

ANIMAL & CELL MODELS