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FLASH GENE
Symbol TRAP1 contributors: mct - updated : 26-04-2012
HGNC name TNF receptor-associated protein 1
HGNC id 16264
Location 16p13.3      Physical location : 3.708.038 - 3.767.598
Synonym name
  • tumor necrosis factor type 1, receptor associated protein
  • heat shock protein 75
  • Synonym symbol(s) HSP75, HSP90L
    DNA
    TYPE functioning gene
    STRUCTURE 59.56 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D16S521 - MPG - HAGH - RPL3 - D16S3024 - CLCN7 - UBE2I - ZNF174 - D16S3070 - ABCA3 - CD63 - TSC2 TSC2 - D16S510 - cen
    Authors Gene Map (98)
    Physical map
    NK4 16p13.3 sarcalumenin ZNF206 16p13.3 zinc finger protein 206 MGC3771 16p13.3 hypothetical protein MGC3771 ZNF205 16p13.3 zinc finger protein 205 ZNF213 16p13.3 zinc finger protein 213 LOC197350 16p13.3 hypothetical protein LOC197350 OR1F1 16p13.3 olfactory receptor, family 1, subfamily F, member 1 OR1F2 16p13.3 olfactory receptor, family 1, subfamily F, member 2 ZNF200 16p13.3 zinc finger protein 200 MEFV 16p13.3 Mediterranean fever FLJ39639 16p13.3 hypothetical protein FLJ39639 ZNF263 16p13.3 zinc finger protein 263 TIGD7 16p13.11 tigger transposable element derived 7 ZNF75A 16p13.11 zinc finger protein 75a LOC390670 16 similar to ribosomal protein L7-like 1 OR2C1 16p13.3 olfactory receptor, family 2, subfamily C, member 1 ZNF434 16p13.3 zinc finger protein 434 ZNF174 16p13.3 zinc finger protein 174 FLJ33071 16p13.3 hypothetical protein FLJ33071 LOC388207 16 LOC388207 FLJ14154 16p13.3 hypothetical protein FLJ14154 LOC390671 16 similar to ribosomal protein L18; 60S ribosomal protein L18 KIAA0643 16p13.3 similar to ribosomal protein L18; 60S ribosomal protein L18 NOD3 16p13.3 NOD3 protein BTBD12 16p13.3 BTB (POZ) domain containing 12 LOC283877 16p13.3 hypothetical LOC283877 DNASE1 16p13.3 deoxyribonuclease I TRAP1 15q25-q26 tumor rejection antigen (gp96) pseudogene 1 CREBBP 16p13.3 CREB binding protein (Rubinstein-Taybi syndrome) ADCY9 16p13.3 adenylate cyclase 9 LOC388208 16 LOC388208 SRL 16p13.3 sarcalumenin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2225 76 672 - 2005 16269234
    15 - 2248 62 547 testis 2005 16269234
    15 exons
    19 - 2189 76 669 trachea 2005 16269234
    19 exons
    13 - 2309 54 469 - 2005 16269234
    13 exons
    18 - 2265 76 672 brain 2005 16269234
    18 exons
    18 - 2208 76 672 placenta 2005 16269234
    18 exons
    18 - 2310 79 704 - 2005 16269234
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
     mouthtongue  highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
     female systemplacenta   
    Respiratorylung    
    Urinarykidney    
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text amnion cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mitochondrial localization sequence in the N terminus
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Trap1 (88.5pc)
    homolog to rattus Trap1 (88.5pc)
    Homologene
    FAMILY HSP90 family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • exhibiting ATPase activity
  • might play a role in protecting mitochondria against damaging stimuli via decrease of reactive oxygen species generation
  • protecting cells from oxidative stress and apoptosis
  • mitochondrial survival factor differentially expressed in localized and metastatic prostate cancer compared with normal prostate
  • acts as a molecular chaperone to retinoblastoma protein (Rb) during cellular stress
  • controls cell cycle activity through the tumor necrosis factor pathways
  • mitochondrial chaperone with antioxidant and antiapoptotic functions, involved in multidrug resistance in colorectal carcinoma cells
  • likely reduces the hypertrophy and fibrosis induced by pressure overload through blocking TAK/P38, JNK, and AKT signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • binding to the intracellular domain of tumor necrosis factor type 1 receptor
  • binding to RB1
  • interacting with cyclophilin D and negatively regulating mitochondrial cell death
  • Sorcin (SI) is a new TRAP1 interactor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    prevented cardiac hypertrophy and fibrosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    targeting the TRAP1 pathway with Gamitrinibs could be explored as novel molecular therapy in patients with advanced prostate cancer
    ANIMAL & CELL MODELS