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FLASH GENE

Symbol

TRAK1

contributors: mct - updated : 11-01-2015

HGNC name	trafficking protein, kinesin binding 1
HGNC id	29947

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	EIEE68 epileptic encephalopathy, early infantile, 68
Location	3p22.1      Physical location : 42.132.745 - 42.267.267
Synonym name	OGT(O Glc NAc transferase) interacting protein 106 KDa
Synonym symbol(s)	KIAA1042, OIP106

DNA

TYPE	functioning gene
STRUCTURE	134.52 kb     16 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014965 13 - 4630 NP_055780 - 686 - 2005 15644324 NM_001042646 16 - 5123 NP_001036111 - 953 - 2005 15644324

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Lymphoid/Immune lymph node       highly Urinary bladder       highly Visual eye       highly

cell lineage
cell lines	all cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N-terminal HAP1 conserved domain
	coiled-coil domains interacting with thr TPR of OGT

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,endosome
	intracellular,nucleus
text	colocalizing with POLR2

basic FUNCTION	targeting OGT to transcrtptional complexes for glycosylation of transcriptional proteins
	playing a role with TRAK2 in protein and/or organelle transport in excitable cells in a manner analogous to glutamate receptor-interacting-protein 1
	role in the regulation of HGS-mediated endosomal sorting and have important implications for understanding hypertonia associated with neurological disorders
	pivotal contribution of the endogenous TRAK family of kinesin adaptors TRAK1 and TRAK2 to the regulation of mitochondrial mobility
	role for TRAK1 as an endogenous mediator of mitochondrial trafficking in axons of hippocampal neurons
	central role for TRAK1 and TRAK2 in mitochondrial trafficking mechanisms but suggesing that the contributions of each to the mediation and regulation of this transport may be distinct
	TRAK1 and TRAK2, which link mitochondria to microtubule-based motors, are required for axonal and dendritic mitochondrial motility and utilize different transport machineries to steer mitochondria into axons and dendrites
	pivotal role for TRAK1 and TRAK2 in the transport of mitochondria and in the intracellular transport of GABAA receptors
	HAP1, TRAK1 and TRAK2 have a degree of common function, particularly regarding intracellular receptor trafficking
	kinesin adaptor proteins, TRAK1 and TRAK2, play an important role in mitochondrial transport in neurons
	TRAK1 preferentially controls mitochondrial transport in axons of hippocampal neurons
	in mature hippocampal and cortical neurons, TRAK1 predominantly mediates axonal mitochondrial transport whereas dendritic transport is mediated via TRAK2

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a complex with OGT, POLR2 and transcriptional factors

INTERACTION

DNA

RNA

small molecule

protein	OGT
	interacts with O-GlcNAc transferase, with RHOT1/Miro-1 and RHOT2/Miro-2
	associate with kinesin
	selective binding by TRAK1 and/or TRAK2 to different members of the kinesin transport family or to RHOT1 and RHOT2 may represent crucial regulatory points in controlling the traffic of mitochondrial cargoes in neurons
	TRAK1 binds to both kinesin-1 and dynein/dynactin, is prominently localized in axons, and is needed for normal axon outgrowth
	DISC1 associates robustly with TRAK1 which is, in turn, known to interact with the outer mitochondrial membrane proteins RHOT1/2, linking mitochondria to the kinesin motor for microtubule-based subcellular trafficking
	DISC1 couples to the mitochondrial transport and fusion machinery via interaction with the outer mitochondrial membrane GTPase proteins RHOT1, RHOT2, the TRAK1 and TRAK2 mitochondrial trafficking adaptors, and the mitochondrial fusion proteins (mitofusins)

cell & other

associate with mitochondria

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

EIEE68

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS