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FLASH GENE
Symbol TRAIP contributors: mct - updated : 03-10-2017
HGNC name TRAF interacting protein
HGNC id 30764
Corresponding disease
SCKL9 Seckel syndrome 9
Location 3p21.31      Physical location : 49.866.027 - 49.893.992
Synonym name ring finger protein 206
Synonym symbol(s) RNF206, TRIP, SCKL9, TRIP
EC.number 2.3.2.27
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 27.99 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2042 - 469 - 2016 26781088
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Reproductivefemale systemovary  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING finger motif and a leucine zipper domain
  • a putative coiled-coil domain
  • a conserved PCNA-interacting peptide (PIP) box motif
  • N terminus of TRAIP is crucial for UIMC1 interaction,
  • C terminus of TRAIP is required for TRAIP localization to sites of DNA damage through a direct interaction with RNF20-RNF40
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text
  • localizes to sites of DNA damage and cells lacking TRAIP exhibit classical DNA-damage response-defect phenotypes
  • SUMOylation deficient TRAIP is not retained in the nucleus
  • nucleolar E3 ubiquitin ligase important for cellular proliferation, that is localized close to mitotic chromosomes
    • basic FUNCTION
  • inhibitor of nuclear factor (NF)-kappaB activation by tumor necrosis factor (TNF)
  • required for normal embryonic development
  • overexpression of TRAIP sensitizes cells to TNF-induced apoptosis, an effect that can be reversed by the coexpression of SYK
  • important role of TRAIP in the regulation of cell cycle progression and the tight linkage of its expression to keratinocyte proliferation
  • TRAIP ubiquitin ligase activity is functionally required for the spindle assembly checkpoint control
  • is crucial in early mitotic progression and chromosome alignment defects in the metaphase
  • E3 ubiquitin ligase required for cell proliferation
  • has important functions in mitosis and tumorigenesis
  • promotes DNA damage response during genome replication, and is necessary for efficient cell cycle progression
  • is a PCNA-binding ubiquitin ligase with an important role in protecting genome integrity after obstacles to DNA replication
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the DNA damage response to replication-blocking DNA lesions
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CYLD (CYLD binds to the COOH-terminal end of TRAIP)
  • directly interacts with TRAF2 and acts as a key regulator of TRAF2-mediated NF-KB activation
  • TRAIP/RNF206 is a novel UIMC1-interacting protein and TRAIP is necessary for translocation of UIMC1 to DNA lesions
  • TRAIP (RNF206) is a novel PCNA-interacting factor that has important roles during mammalian replicative stress responses
    • cell & other
    REGULATION
    Other is post-translationally modified by the small ubiquitin-like protein (SUMO)
    ASSOCIATED DISORDERS
    corresponding disease(s) SCKL9
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS