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FLASH GENE
Symbol TRAFD1 contributors: mct/npt - updated : 09-06-2010
HGNC name TRAF-type zinc finger domain containing 1
HGNC id 24808
Location 12q24.13      Physical location : 112.563.348 - 112.591.407
Synonym name
  • FLN29 gene product
  • protein FLN29
  • Synonym symbol(s) FLN29
    DNA
    TYPE functioning gene
    STRUCTURE 28.06 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3196 - 582 - Mashima (2005)
    12 - 2665 - 582 - Mashima (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunespleen   highly
     tonsils   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a TRAF6-related zinc finger motif
  • TRAF family member-associated NF-kappaB activator-related sequences
  • HOMOLOGY
    Homologene
    FAMILY
  • TRAF family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may function as a lipopolysaccharide (LPS)-inducible negative regulator in innate immunity
  • may be involved in endotoxin tolerance
  • a new negative feedback regulator of TLR signaling
  • suppress Toll-like receptor 4-mediated NF-kappaB activation by binding to TRAF6 (Sanada 2008)
  • in addition to playing a negative regulatory role in the TLR4 signaling pathway, negatively regulates the RARRES3-like helicase signaling pathway at the level of MAVS/TRAF6 and MAVS/TRAF3 complexes (Sanada 2008)
  • may play a role in the resistance of cancer cells to oncotherapeutics designed to trigger programmed cell death via protein-protein interactions (Sauve 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • could interact with TICAM1, MAVS, TRAF3, and TRAF6 (Sanada 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS