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FLASH GENE
Symbol TRAF7 contributors: mct/npt/pgu - updated : 05-09-2018
HGNC name TNF receptor-associated factor 7
HGNC id 20456
Corresponding disease
MRSHDL mental retardation, syndromic with heart defects and limb anomalies
Location 16p13.3      Physical location : 2.205.798 - 2.228.129
Synonym name
  • ring finger and WD repeat domain 1
  • RING finger protein 119
  • Synonym symbol(s) RNF119, DKFZp586I021, RFWD1, MGC7807
    EC.number 2.3.2.27
    DNA
    TYPE functioning gene
    STRUCTURE 22.33 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3676 - 670 - 2004 15001576
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivefemale systemuterus   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal cys/his-rich region
  • a RING-type zinc finger
  • a coiled-coil motif, required for association with IKBKG
  • a TRAF domain
  • lacks the conserved C-terminal domain found in TRAF16, and instead it has several WD40 repeats in its C-terminal domain , C-terminal WD40 domain has been shown to facilitate TRAF7 interaction with MAP3K3
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor receptor-associated factor (TRAF) protein family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • may have E3 ubiquitin ligase activity
  • potentiates MAP3K3-induced AP1 and CHOP activation
  • induces caspase-dependent apoptosis when overexpressed
  • involved in MAP3K3 signaling and apoptosis
  • potentiated MAP3K3-mediated AP1 and CHOP activation and induced apoptosis through distinct domains
  • negatively regulates MYB activity by sequestering MYB to the cytosol via sumoylation
  • involved in the signal transduction pathway that links Toll-like receptor 2 stimulation to activation of NFKB transcription factor
  • TRAF7 also influences RELA nuclear distribution
  • negative role for TRAF7 in NFKB signaling
  • acts as a negative regulator of NFKBB and functions as a positive regulator of AP1
  • important role for TRAF7 in the activation of JNK following TNF stimulation and clearly point to an involvement of this protein in regulating the turnover of CFLAR and, consequently, cell death
  • is involved in signal transduction pathways that lead either to activation or repression of NFKB1 transcription factor
  • E3 ubiquitin ligase for several proteins involved in the activation of TLR-dependent NF-kappaB signaling
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to MYB and stimulates its sumoylation (bound to the DNA-binding domain of MYB via its WD40 repeats and TRAF7 has an E3 ubiquitin ligase activity for self-ubiquitination)
  • direct MYOD1 target
  • IKBKG, the NF-KB essential modulator, is a TRAF7-interacting protein
  • interacting with IKBKG, and RELA (promotes Lys-29-linked polyubiquitination of IKBKG and RELA that results in lysosomal degradation of both proteins and altered activation)
  • TRAF7-mediated ubiquitination of TP53 plays a critical role in breast cancer development
  • TRAF7 interacts by its WD40 domain with MAP3K3 and coexpression of TRAF7 with MAP3K3 activates the JNK and MAPK14 signaling pathways that affect cell proliferation, differentiation, survival, and migration
  • TRAF7 links TNFR family proteins to signaling pathways, thus participates in regulating cell death and survival mediated by TNF family ligands
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRSHDL
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    accelerates myogenesis, in part through downregulation of nuclear factor-kappaB (NF-KB) activity
    tumoral somatic mutation      
    in adenomatoid tumors of the male and female genital tracts
    tumoral germinal mutation      
    in 60p100 of intraneural perineuriomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS