protein
| interacting with CD30 in NF-kappa B activation interaction |
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TRAF5 plays a crucial role in TNFRSF18-induced signaling pathways that augment T cell activation |
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related ubiquitin ligase TRAF5 is a downstream target of MAVS that mediates both IRF3 and NF-kappaB activation |
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NUMBL interacted directly with TRAF5, which signals upstream and is required for the activation of NFKB, and committed it to proteasomal degradation by promoting K48-linked polyubiquitination of TRAF5 |
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TRAF5 negatively regulated the association of TAB2 with its signaling partner TRAF6 after TLR ligation in B cells |
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is a negative regulator of the IL6R signaling pathway that limits the induction of proinflammatory CD4(+) T cells that require IL6 for their development |
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TRAF5, known as an E3 ubiquitin protein ligase and signal transducer, interacts with and ubiquitinates RORC via Lys-63-linked polyubiquitination, and stabilizes the RORC protein level depending on its RING finger domain |
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increasing TRAF5 ameliorates nonalcoholic fatty liver by blocking MAPK8 activity |
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TRAF5 binds to the signal-transducing receptor IL6ST through the C-terminal TRAF domain and inhibits Th17 development mediated by IL6 |