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FLASH GENE
Symbol TRAF1 contributors: mct/npt/pgu - updated : 05-03-2016
HGNC name TNF receptor-associated factor 1
HGNC id 12031
Location 9q33.2      Physical location : 123.664.671 - 123.691.451
Synonym name
  • Epstein-Bar virus-induced protein 6
  • tumor necrosis factor (TNF)-receptor-associated factor 1
    • Synonym symbol(s) EBI6, MGC:10353
    DNA
    TYPE functioning gene
    STRUCTURE 24.50 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4449 - 416 - 1994 8069916
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Lymphoid/Immunetonsils    
    Reproductivemale systemtestis   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta weakly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal stretch of zinc finger
  • a (coiled coil) leucine zipper domains
  • a C terminal TRAF domain, (TRAF1-(164-416), required for self association (dimerization) and receptor binding
    • HOMOLOGY
    Homologene
    FAMILY
  • TRAF family
    • CATEGORY adaptor , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inducible molecule taking part in the signal transduction of TNFR2 (TNFRSF1B),LTBR, CD40,(TNFRSF5, CD30 (TNFRSF8, LMP1
  • involved in the blockage of apoptotic pathway
  • regulates CD40-induced TRAF2-mediated NF-kappaB activation
  • differentially affects TRAF2 recruitment and activation of NF-kappaB by members of the TNF receptor family
  • substrate of PKN1 kinase activity, and the phosphorylation event is required for attenuating downstream kinase activities
  • important molecule mediating both the TNFRSF8 signaling-dependent and independent NF-kappaB activation, which prevents the lymphoma cells from spontaneous and induced apoptosis
    • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homodimerizing,heterodimerizing with TRAF2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • implicated in TNFR mediated activation of NFKB and MAPK8 (JNK)
  • recruiting BIRC2,BIRC3 to TNFR2 (TNFRSF1B)
  • associating with EBV-transforming protein LMP
  • TRAF1 enhances the activation of tumor necrosis factor receptor 2 (TNFSFR1B) induced by NFKB1
    • cell & other
    REGULATION
    inhibited by inactivated by caspase during FAS ligand mediated apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Hodgkin's disease and EBV, lymphoid cells
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism other a common genetic variant at the TRAF1-C5 locus is associated with an increased risk of anti-CCP-positive rheumatoid arthritis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS