Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TRABD2A contributors: mct - updated : 30-10-2017
HGNC name TraB domain containing 2A
HGNC id 27013
Location 2p11.2      Physical location : -
Synonym name
  • metalloprotease TIKI1
  • UPF0632 protein C2orf89
  • Synonym symbol(s) C2orf89, TIKI1
    DNA
    TYPE functioning gene
    STRUCTURE 60.33 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3533 - 333 - 2012 22726442
    7 - 1975 - 505 - 2012 22726442
    6 - 1839 - 456 - 2012 22726442
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal signal peptide
  • an ectodomain, referred to a TIKI homology domain that acts likely as a protease to cleave eight N-terminal AAs of a Wnt protein, resulting in oxidized Wnt oligomers that exhibit normal secretion but minimized receptor-binding capability
  • a transmembrane domain at the C-terminus
  • secondary structure two pairs of potential disulfide bonds that reside outside the beta-sheet catalytic core but likely assist the folding of the TIKI domain
    conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to TRABD2B
    Homologene
    FAMILY Tiki family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acts in both Wnt-producing and Wnt-responding cells
  • required for head formation via cleavage and inactivation of Wnt ligands
  • is required for anterior development, for anterior neural patterning
  • TRABD2A, TRABD2B exhibit specific expression during embryogenesis
  • TRABD2A protease activity was shown to be metal ion-dependent and was inhibited by chelating agents and thus was tentatively proposed to be a metalloprotease
  • mis-regulation of TRABD2A, TRABD2B in human cancer and diseases
  • TRABD2A, TRABD2B, are Wnt inhibitors that act by cleaving the Wnt amino-terminal region to inactivate specific Wnt ligands
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRABD2A, TRABD2B result in a WNT3A modification that minimizes Wnt3a activity but not secretion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    of TRABD2A, TRABD2B in osteosarcoma may participate in the progression of osteosarcoma and restoring its expression was able to impair the growth of osteosarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS