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FLASH GENE

Symbol

TRA@

contributors: mct - updated : 23-02-2013

HGNC name	T cell receptor alpha locus
HGNC id	12027

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q11.2      Physical location : -
Genatlas name	T cell receptor alpha cluster, including, from the centromere to the telomere, the TRAV@ cluster (54 genes), the TRAJ@ cluster (61 genes) and a unique TRAC gene (see symbols), rearranged during thymocyte ontogenesis to produce the alpha suunit of the TCR-2 (alpha-beta), T cell receptor
Synonym symbol(s)	TCRA

DNA

TYPE	cluster
SPECIAL FEATURE
text	the TRD@ cluster is embedded in the TRA@ cluster
STRUCTURE	1000.00 kb     0 Exon(s)

regulatory sequence	Binding site   enhancer
text structure	a locus control region LCR
	an enhancer at the 3'end of the cluster, telomeric to TRAC

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - 5' - TRAV@ - TRD@ - BEAD1 - TRAJ@ - TRAC - 3' - qter
Authors	Zhong (97), IMGT

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Lymphoid/Immune lymph node

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text

thymocyte

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a large N-terminal extracellular segment, folded into two Ig-like domains with both ends joined by a disulfide bond, one variable and forming the antigen-binding site with the cognate beta domain, one constant
	a transmembrane segment (TM1)
	a short cytoplasmic tail

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

encoding the T cell receptor, alpha chain repertoire

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	cellular immunity

PATHWAY

metabolism

signaling

a component

component of the T cell receptor, type 2, which is a disulfide bound heterodimer of an alpha and a beta chain, associated to the CD3 complex

INTERACTION

DNA

RNA

small molecule	other,
	binding the fragmented antigens in a MHC restricted way

protein

cell & other

antigen presenting cell

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS