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FLASH GENE
Symbol TRA2B contributors: mct - updated : 12-04-2014
HGNC name splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)
HGNC id 10781
Location 3q27.3      Physical location : 185.632.359 - 185.655.924
Synonym name
  • transformer 2, Drosophila homolog of beta
  • SR-like splicing factor
  • transformer 2 homolog
  • Synonym symbol(s) SRFS10, HTRA2B, DKFZp686F18120, TRAN2B, SFRS10, TRA2-BETA, Htra2-beta
    DNA
    TYPE functioning gene
    STRUCTURE 23.57 kb     10 Exon(s)
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site   enhancer
    motif repetitive sequence   ALU
    text structure four enhancers in exon 2, activating its inclusion
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4290 33.67 288 - 1998 9790768
  • hTRA2-beta 1
  • lacking exon 2
  • 8 - 4156 - 188 widely 1998 9790768
  • hTRA2-beta 2
  • exon 1 and 2A, lacking the first RS domain
  • - - - - - untranslated 1998 9790768
    lacking exon 2, 3, internal initiation site exon 4, lacking the first RS domain, lacking the first RS domain
    - - - - 188 minor, widely brain, liver, testis 1998 9790768
    internal initiation site exon 4
    - - - - 188 minor, brain, liver, testis 1998 9790768
    internal initiation site exon 4
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemtestis   
    Visualeyeretina    Mus musculusFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal RNP- RNA recognition motif (RRM) motif and N-terminal RS1 domain, essential for the splicing activator function of TRA2B
  • two C terminal SR- rich domains, the second interrupted by a glycine-rich region
  • HOMOLOGY
    interspecies ortholog to Drosophila transformer 2
    Homologene
    FAMILY
  • splicing factor SR family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • mediating protein-protein interaction within the intron during spliceosome assembly
  • independently binding to exonic enhancer sequences and recruiting components to adjacent introns for splice-site recognition and alternative splicing
  • restoration of full-length SMN expression to SMN2 (therapeutic strategy of SMA)
  • possible role in the regulation of vascular smooth muscle cells proliferation (especially in stress cell)
  • is a novel mediator of vascular smooth muscle diversification
  • may play a role in aberrant MAPT exon 10 alternative splicing and in the pathogenesis of tauopathies
  • regulates a number of splicing switches including activation of the human testis-specific exon HIPK3-T
  • is essential for proper development of the cerebral cortex.
  • splicing factor that can modulate splicing inclusion of exons by specifically detecting GAA-rich binding motifs and its absence causes early embryonic lethality in mice
  • is involved in splicing processes of NASP, MAPT, SMN
  • pivotal role for the developing central nervous system
  • regulates splicing events essential for maintaining neuronal viability during development
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the E commitment complex in the spliceosome assembly pattern
  • complex SFRS10/RBMX and SMN2 exon 7 RNA
  • complexing with HIPK3 (complex regulatory network involving alternative splicing in the testis)
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • RBMY in splicing in spermatocytes
  • colocolizing and interacting with SFRS2
  • RBMX to facilitates SMN exon 7 inclusion
  • PPP1R1B changes the usage of TRA2B dependent alternative exons in a concentration-dependent manner, suggesting that the PPP1R1B:TRA2B interaction is a molecular link between signaling pathways and pre-mRNA processing
  • interacting with HIPK3 (enhancing the incorporation of a novel testis-specific alternative exon)
  • by regulating the splicing of PPP1R12A, sets the sensitivity of smooth muscle to cGMP-mediated relaxation
  • interact directly with the RBMY protein which is implicated in liver cancer
  • cell & other
  • binds a matrix of AGAA-rich sequences mapping frequently to exons
  • REGULATION
    activated by the 68 kD subunit cleavage factor Im involved in transcriptional control ad RNA processing
    inhibited by hyperphosphorylation (reducing its binding to RNA)
    Other control of the cellular concentration by a negative feed-back loop regulating the splicing of exon 2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS