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FLASH GENE
Symbol TRA@ contributors: mct - updated : 23-02-2013
HGNC name T cell receptor alpha locus
HGNC id 12027
Location 14q11.2      Physical location : -
Genatlas name T cell receptor alpha cluster, including, from the centromere to the telomere, the TRAV@ cluster (54 genes), the TRAJ@ cluster (61 genes) and a unique TRAC gene (see symbols), rearranged during thymocyte ontogenesis to produce the alpha suunit of the TCR-2 (alpha-beta), T cell receptor
Synonym symbol(s) TCRA
DNA
TYPE cluster
SPECIAL FEATURE
text the TRD@ cluster is embedded in the TRA@ cluster
STRUCTURE 1000.00 kb     0 Exon(s)
regulatory sequence Binding site   enhancer
text structure
  • a locus control region LCR
  • an enhancer at the 3'end of the cluster, telomeric to TRAC
  • MAPPING cloned Y linked Y status confirmed
    Map cen - 5' - TRAV@ - TRD@ - BEAD1 - TRAJ@ - TRAC - 3' - qter
    Authors Zhong (97), IMGT
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Lymphoid/Immunelymph node    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text thymocyte
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a large N-terminal extracellular segment, folded into two Ig-like domains with both ends joined by a disulfide bond, one variable and forming the antigen-binding site with the cognate beta domain, one constant
  • a transmembrane segment (TM1)
  • a short cytoplasmic tail
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION encoding the T cell receptor, alpha chain repertoire
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text cellular immunity
    PATHWAY
    metabolism
    signaling
    a component component of the T cell receptor, type 2, which is a disulfide bound heterodimer of an alpha and a beta chain, associated to the CD3 complex
    INTERACTION
    DNA
    RNA
    small molecule other,
    binding the fragmented antigens in a MHC restricted way
    protein
    cell & other antigen presenting cell
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS