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FLASH GENE
Symbol TPTE2 contributors: - updated : 17-03-2005
HGNC name transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
HGNC id 17299
Location 13q12.11      Physical location : 19.997.020 - 20.110.903
Synonym name
  • transmembrane Phosphatase with TEnsin homology 2
  • TPTE and PTEN homologous Inositol lipid Phosphatase
  • PTEN-related tyrosine phosphatase with four potential transmembrane domains
  • Synonym symbol(s) TPIP
    DNA
    TYPE functioning gene
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1735 - 445 testis, brain, stomach Tapparel
    has N-terminal transmembrane domains and appears to be localized on the endoplasmic reticulum.
    - - 1607 - 337 restricted to testis Tapparel
  • lacks the transmembrane domains and has a truncated C2 domain
  • lacks detectable phosphatase activity and is cytosolic
  • - - 1966 - 522 - Tapparel
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    Reproductivefemale systemuterus   
     male systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • several transmembrane spanning domains
  • a C-terminal calcium-dependent membrane targeting module (C2 domain)
  • HOMOLOGY
    intraspecies homolog to TPTE
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • playing a role in regulating phosphoinositide signalling on the endoplasmic reticulum, and may be also representing a tumour suppressor and functional homologue of PTEN in some tissues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS