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FLASH GENE
Symbol TPT1 contributors: mct/npt/pgu - updated : 23-03-2010
HGNC name tumor protein, translationally-controlled 1
HGNC id 12022
Location 13q14.13      Physical location : 45.911.303 - 45.915.297
Synonym name
  • fortilin
  • translationally controlled tumor protein
  • histamine realeasing factor
  • immunoglobulin E-dependent
  • recombinant histamine releasing factor
  • Synonym symbol(s) TCTP, HRF, FLJ27337, p02, p23
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    Binding site   cAMP
    MAPPING cloned Y linked N status confirmed
    Map cen - D13S240 - D13S219 - D13S1 - D13S263 - D13S291 - TPT1 - D13S190 - D13S126 - D13S118 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 polyA site 829 19 172 - 2006 16859841
  • contain the same coding region and 5'UTR than variant 2
  • differ in the length of 3'UTR because of alternative poly-A signals
  • - polyA site 1200 19.5 172 - 2006 16859841
  • contain the same coding region and 5'UTR than variant 1
  • differ in the length of 3'UTR because of alternative poly-A signals
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Digestiveintestinesmall intestine   
     liver   highly
    Reproductivemale systemprostate  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion prostatic fluid
    at STAGE
    physiological period embryo, fetal
    cell cycle     cell cycle, interphase, M
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus (AAs 1-72) is required for its Ca2+-binding
  • HOMOLOGY
    interspecies homolog to rattus Tpt1 (95,93 pc)
    homolog to murine Tpt1 (95,93 pc)
    Homologene
    FAMILY
  • TCTP family
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • in prostate epithelial cells detected the protein in the cytoplasm in interphase and colocalized with tubulin during mitosis
  • present both in the cytosol and nucleus
  • colocalizes with CHFR to the mitotic spindle
  • basic FUNCTION
  • preferentially synthesized in cells during the early growth phase of some types of tumor but which is also expressed in normal cells
  • antiapoptotic protein involved in cell survival and apoptosis regulation
  • Na/K-ATPase-suppressive activity
  • possesses potent anti-apoptotic activity
  • intracellular Ca2+ scavenger, protecting cells against Ca2+-dependent apoptosis by binding and sequestering Ca2+ from the downstream Ca2+-dependent apoptotic pathways
  • involved in TSC22D1 destabilization via their interaction
  • plays a very modest role in thymocyte development, but is critical for peripheral T cell maintenance and TCR-mediated cell proliferation
  • may belong to a novel small molecular weight heat shock protein with chaperone-like activity
  • identified on the surface of nanovesicles purified from medium conditioned by apoptotic endothelial cells, and TCTP-bearing nanovesicles are a novel component of the paracrine apoptotic program of potential importance in vascular repair
  • survival factor that protects cancer cells from oxidative stress-induced cell-death
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    bind Ca2+ (must bind Ca2+ in order to protect cells against Ca2+-dependent apoptosis)
    protein
  • EEF1D
  • interacting with TSC22D1
  • binding to dihydroartemisinin (DHA)
  • interacting with STEAP3
  • interacts with RHEB and activates the MTOR pathway
  • possible CHFR-interacting partner (CHFR-TPT1 interaction is stable throughout the cell cycle, but it could be diminished by the complete depolymerization of the microtubules, providing a possible mechanism where CHFR could be the sensor that detects microtubule disruption and then activates the prophase checkpoint)
  • cell & other
    REGULATION
    induced by regulated by CREB transcription factors
    inhibited by SNX6
    Other reduced cellular levels in varieties of cells after binding to dihydroartemisinin and increased ubiquitination
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    tumoral     --over  
    in many cancers
    constitutional     --low  
    may result in sequestration of active cofilin by a monomeric pool of actin
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    for fortilin-overexpressing cancers
    cancer  
    is a "stress hallmark" that may be exploited as a therapeutic target to decrease the resistance of cancer cells to anticancer therapy
    ANIMAL & CELL MODELS