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FLASH GENE
Symbol TPST1 contributors: mct - updated : 03-12-2011
HGNC name tyrosylprotein sulfotransferase 1
HGNC id 12020
Location 7q11.21      Physical location : 65.670.258 - 65.825.437
EC.number 2.8.2.20
DNA
TYPE functioning gene
STRUCTURE 155.18 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC392053 7 similar to Opioid binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML) ZFD25 7q11.2 similar to Opioid binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML) LOC253883 7q11.21 similar to myelin protein zero-like 1; protein zero related ZNF138 7q11.21-q11.23 zinc finger protein 138 (clone pHZ-32) LOC168474 7q11.21 selenophosphate synthetase pseudogene MGC12518 7q11.21 similar to ZINC FINGER PROTEIN 257 (BONE MARROW ZINC FINGER 4) (BMZF-4) LOC389505 7 LOC389505 ZNF117 7q11.2 zinc finger protein 117 (HPF9) H-plk 7q11.21 Krueppel-related zinc finger protein FLJ25037 7q11.21 hypothetical protein FLJ25037 LOC389506 7 LOC389506 ZNF92 19p13.1-p12 zinc finger protein 92 (HTF12) LOC392054 7 similar to protein kinase related to Raf protein kinases; Method: conceptual translation supplied by author LOC389507 7 similar to hypothetical protein FLJ25037 LOC392055 7 similar to protein kinase related to Raf protein kinases; Method: conceptual translation supplied by author LOC392056 7 similar to metabotropic glutamate receptor 8; G protein-coupled receptor, family C, group 1, member H LOC389508 7 similar to hypothetical protein MGC16733 similar to CG12113 LOC389509 7 similar to RIKEN cDNA 2610034N24 LOC389510 7 LOC389510 DKFZp434F142 7q11.21 hypothetical protein DKFZp434F142 LOC154807 GUSB 7q22.1 glucuronidase, beta LOC392057 7 similar to Gcp16 protein ASL 7cen-q11.2 argininosuccinate lyase RCP9 7q11.21 calcitonin gene-related peptide-receptor component protein TPST1 7q11.21 tyrosylprotein sulfotransferase 1 LOC285908 7q11.21 hypothetical protein LOC285908 TCEB1P 5q31.1 transcription elongation factor B (SIII), polypeptide 1 pseudogene LOC389511 7 similar to RAB guanine nucleotide exchange factor (GEF) 1 LOC346329 7q11.21 similar to Guanine nucleotide-binding protein, alpha-11 subunit (GL2) LOC389512 7 LOC389512 LOC154880 7q11.21 similar to 60S ribosomal protein L35 KCTD7 7q11.21 potassium channel tetramerisation domain containing 7 RABGEF1 7q11.21 RAB guanine nucleotide exchange factor (GEF) 1 LOC285911 7q11.22 similar to ribosomal protein L31 FLJ10099 7q11.22 hypothetical protein FLJ10099 SBDS 7q11.21 Shwachman-Bodian-Diamond syndrome FLJ10900 7q11.22 hypothetical protein FLJ10900 LOC155081 7q11.22 hypothetical gene supported by AL137266 LOC389513 7 similar to PMS5 homolog mismatch repair protein - human FLJ13195 7p11.2-q11.2 hypothetical protein FLJ13195 similar to stromal antigen 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2062 - 370 - 2006 16859706
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Nervousnerve   highly
Reproductivefemale systemplacenta  highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N and C-terminal flanking residues,
  • a transmembrane domain act in targeting and retention of the enzyme to the trans-Golgi compartment
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane glycoproteins
    basic FUNCTION
  • catalyzing tyrosine o-sulfation of proteins
  • acting in targeting and retention of the enzyme to the trans-Golgi compartment
  • transfer the sulfate moiety to proteins predominantly designated for secretion
  • may be functional as homodimer/oligomer in the trans-Golgi compartment
  • involved in photoreceptor outer segment morphogenesis, retinal function and retinal anatomy
  • tyrosine O-sulfation is a post-translational modification catalyzed by two tyrosylprotein sulfotransferases (TPST1 and TPST2) in the trans-Golgi network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in shear stress involves tyrosine kinase (Goettsch 2002)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS