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FLASH GENE
Symbol TPSG1 contributors: - updated : 08-07-2003
HGNC name tryptase gamma 1
HGNC id 14134
Location 16p13.3      Physical location : 1.271.650 - 1.275.254
Synonym name
  • serine protease 31
  • transmembrane tryptase
  • lung tryptase
  • mast cell tryptase
  • skin tryptase
  • pituitary tryptase
  • Synonym symbol(s) TMT, PRSS31, trpA
    EC.number 3.4.21.59
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text alpha I, beta I, beta II and gamma I (beta I has an allelic variant named alpha II, beta II has an allelic variant beta III and gamma I has an allelic variant gamma II)
    STRUCTURE 3.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4929 33.8 321 - Caughey
    - - 5281 33.8 321 - Caughey
    - - - - - - Caughey
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Endocrineneuroendocrinepituitary   
    Reproductivemale systemprostate  moderately
    Respiratorylung    
    Skin/Tegumentskin    
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     mast cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • peptidase S1 domain
  • C terminal hydrophobic domain (membrane anchor)
  • conjugated GlycoP
    mono polymer polymer
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies ortholog to murine Tpsg1
    homolog to Drosophila CG11192
    Homologene
    FAMILY
  • trypsine-like serine protease/prostasine family
  • peptidase family S1
  • tryptase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane anchored by a C-terminal hydrophobic domain
    basic FUNCTION
  • serine protease cleaving the Arg-Lys bond (chymotrypsin and trypsin activites)
  • implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heparin-stabilized tetramers
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS