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FLASH GENE
Symbol TPSB2 contributors: - updated : 30-05-2007
HGNC name tryptase beta 2
HGNC id 14120
Location 16p13.3      Physical location : 1.278.336 - 1.280.185
Synonym name
  • tryptase beta II
  • tryptase beta III
  • mast cell protease
  • lung tryptase
  • skin tryptase
  • Synonym symbol(s) beta II, TPSB1, TPS2
    EC.number 3.4.21.59
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text
  • tryptase,including a cluster of three isoforms beta1,beta2,beta3,an alpha-like gene and a pair of hybrid genes related partly to alpha/beta-tryptases
  • alpha I,beta I,beta II and gamma I (beta I has an allelic variant named alpha II,beta II has an allelic variant beta III and gamma I has an allelic variant gamma II)
  • STRUCTURE 1.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text beta 2 and beta 3 an allelic
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     mast cell
    cell lineage
    cell lines
    fluid/secretion secreted
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains a peptidase S1 domain
    conjugated GlycoP
    mono polymer homomer , tetramer
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies ortholog to Drosophila CG18735
    Homologene
    FAMILY
  • peptidase family S1
  • family of trypsin-like serine proteases
  • tryptase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    text released from the secretory granules upon mast cell activation
    basic FUNCTION
  • serine protease cleaving the Arg-Lys bond
  • implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders
  • major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation
  • response of this cell type
    CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heparin-stabilized tetramers
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS