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FLASH GENE

Symbol

TPSAB1

contributors: npt - updated : 01-07-2006

HGNC name	tryptase alpha/beta 1
HGNC id	12019

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.3      Physical location : 1.290.677 - 1.292.554
Synonym name	tryptase beta 1
	tryptase, alpha
	lung tryptase
	mast cell protease II
Synonym symbol(s)	TPS1, TPS2, TPSB1, alpha II
EC.number	3.4.21.59

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	tryptase, including a cluster of three isoforms beta1, beta2, beta3, an alpha-like gene and a pair of hybrid genes related partly to alpha/beta-tryptases
STRUCTURE	1.00 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	beta 1 and alpha 2 allelic

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 1194 - 275 - -         30 - - -

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine large intestine colon   highly   stomach       highly Endocrine pancreas       highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective

cells

System Cell Pubmed Species Stage Rna symbol   mast cell

cell lineage
cell lines
fluid/secretion	secreted

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	30 AA leader sequence
	245 AA catalytic region
	two putative N linked carbohydrate binding sites

mono polymer

homomer , tetramer

HOMOLOGY

Homologene

FAMILY

peptidase family S1

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,granule

basic FUNCTION	serine protease cleaving the Arg-Lys bond
	major neutral protease present in mast cells and secreted upon the coupled activation-degranulation response of this cell type

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

a cluster of three isoform beta1, beta2, beta3 and TPS1

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS